Li Xiaowan, Zhang Liyan, Du Yingying, Shen Yiru, Gong Yuanzhi, Wang Junjie, Zhou Juan, Wang Sheng
Intensive Care Medical Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Diabetol Metab Syndr. 2025 Mar 24;17(1):98. doi: 10.1186/s13098-025-01640-9.
BACKGROUND: This study intends to examine any possible correlation between monocyte-to-lymphocyte ratio (MLR) and cardiovascular diseases (CVD). METHODS: Data from the 1999-2020 National Health and Nutrition Examination Survey (NHANES) in the USA were analyzed. Heart attacks, angina pectoris, congestive heart failure (CHF), coronary heart disease (CHD), and stroke were all covered by CVD. The independent relationships between these cardiovascular events and MLR levels, as well as other inflammatory indices (system inflammation response index (SIRI), aggregate index of systemic inflammation (AISI), and C-reactive protein-to-albumin ratio (CAR)), were investigated. Furthermore, interaction tests and subgroup analysis were performed. Diagnostic capacities were also predicted and compared using receiver operating characteristic (ROC) curves. RESULTS: Males made up 49.63% of the 46,289 people who were recruited in this study. The prevalence of CVD and its events were as follows: CHF at 2.99%, CHD at 3.72%, angina pectoris at 2.57%, heart attacks at 3.94%, and stroke at 3.48%, with CVD itself at 7.98%. MLR and CVD were positively correlated. Specifically, smooth curve fittings also found a non-linear relationship between MLR and CVD. Moreover, higher MLR levels were linked to increased rates of CHF, CHD, and strokes. SIRI was also found to have a positive correlation with CVD. MLR outperformed other inflammatory indices (SIRI, AISI, and CAR) in terms of discriminative capacity and accuracy in predicting CVD, CHF, CHD, angina pectoris, heart attack, and stroke, according to ROC analysis. CONCLUSIONS: Compared with other inflammatory indicators (SIRI, AISI, and CAR), MLR appears to be a better inflammatory index for predicting CVD, CHF, CHD, angina pectoris, heart attack, and stroke. American adults with elevated MLR and SIRI should be aware of the possible harm caused by CVD. Causal inference is, however, limited by the cross-sectional design and dependence on self-reported data. Further longitudinal studies are needed to validate these findings.
背景：本研究旨在探讨单核细胞与淋巴细胞比值（MLR）与心血管疾病（CVD）之间是否存在任何可能的关联。 方法：对美国1999 - 2020年国家健康与营养检查调查（NHANES）的数据进行分析。CVD涵盖心脏病发作、心绞痛、充血性心力衰竭（CHF）、冠心病（CHD）和中风。研究了这些心血管事件与MLR水平以及其他炎症指标（全身炎症反应指数（SIRI）、全身炎症聚集指数（AISI）和C反应蛋白与白蛋白比值（CAR））之间的独立关系。此外，进行了交互作用测试和亚组分析。还使用受试者工作特征（ROC）曲线预测和比较了诊断能力。 结果：本研究招募的46289人中，男性占49.63%。CVD及其事件的患病率如下：CHF为2.99%，CHD为3.72%，心绞痛为2.57%，心脏病发作为3.94%，中风为3.48%，CVD本身为7.98%。MLR与CVD呈正相关。具体而言，平滑曲线拟合也发现MLR与CVD之间存在非线性关系。此外，较高的MLR水平与CHF、CHD和中风的发生率增加有关。还发现SIRI与CVD呈正相关。根据ROC分析，在预测CVD、CHF、CHD、心绞痛、心脏病发作和中风方面，MLR在判别能力和准确性方面优于其他炎症指标（SIRI、AISI和CAR）。 结论：与其他炎症指标（SIRI、AISI和CAR）相比，MLR似乎是预测CVD、CHF、CHD、心绞痛、心脏病发作和中风的更好的炎症指标。MLR和SIRI升高的美国成年人应意识到CVD可能造成的危害。然而，因果推断受到横断面设计和对自我报告数据的依赖的限制。需要进一步的纵向研究来验证这些发现。
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