Zhang Tian Yang, Chen Hai Long, Shi Yanyu, Jin Ying, Zhang Yuan, Chen Ying
College of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Department of Chronic Disease Clinic, Changchun NanGuan District Hospital, Changchun, China.
Front Cardiovasc Med. 2024 Aug 12;11:1439913. doi: 10.3389/fcvm.2024.1439913. eCollection 2024.
Coronary heart disease (CHD) is one of the common chronic diseases in clinical practice, often accompanied by inflammatory reactions. In recent years, the system inflammation response index (SIRI) has aroused researchers' interest as a novel inflammatory biomarker. This study aims to explore the relationship between the SIRI and CHD through the National Health and Nutrition Examination Survey (NHANES) database.
We conducted a cross-sectional study and analyzed participants aged 40 and above with complete data from the NHANES survey years 2007-2016. Logistic regression analysis was used in this study to explore the relationship between the risk of CHD and SIRI. Stratified subgroup analysis was conducted based on age, gender, race, education level, body mass index (BMI), smoking status, drinking, hypertension, diabetes and angina pectoris to evaluate the relationship between SIRI and CHD in different populations. Additionally, restricted cubic spline (RCS) analysis was employed to investigate whether there is a nonlinear association between SIRI and CHD.
A total of 6374 eligible participants were included, among whom 387 were diagnosed with CHD. The SIRI levels in the CHD group were significantly higher than those in the non-CHD group. After adjusting for potential confounders, an elevated SIRI level was associated with an increased risk of CHD, with an odds ratio of 1.12, 95% CI: (1.03, 1.22), = 0.008. Subgroup analysis results indicated a significant interaction between SIRI and CHD among genders ( for interaction <0.05), especially in females. In contrast, no significant interaction was observed among age, race, education level, BMI, smoking status, drinking, hypertension, diabetes and angina pectoris ( for interaction >0.05). The RCS analysis showed a significant linear relationship between SIRI and CHD ( for non-linearity >0.05), with an inflection point at 2.86.
Our study indicates that an elevated system inflammation response index is associated with a higher risk of CHD. Particularly among women.
冠心病（CHD）是临床常见的慢性疾病之一，常伴有炎症反应。近年来，系统炎症反应指数（SIRI）作为一种新型炎症生物标志物引起了研究人员的关注。本研究旨在通过美国国家健康与营养检查调查（NHANES）数据库探讨SIRI与CHD之间的关系。
我们进行了一项横断面研究，分析了2007 - 2016年NHANES调查中年龄在40岁及以上且数据完整的参与者。本研究采用逻辑回归分析来探讨冠心病风险与SIRI之间的关系。基于年龄、性别、种族、教育水平、体重指数（BMI）、吸烟状况、饮酒、高血压、糖尿病和心绞痛进行分层亚组分析，以评估不同人群中SIRI与CHD之间的关系。此外，采用受限立方样条（RCS）分析来研究SIRI与CHD之间是否存在非线性关联。
共纳入6374名符合条件的参与者，其中387人被诊断为冠心病。冠心病组的SIRI水平显著高于非冠心病组。在调整潜在混杂因素后，SIRI水平升高与冠心病风险增加相关，比值比为1.12，95%置信区间：（1.03，1.22），P = 0.008。亚组分析结果表明，SIRI与CHD在性别之间存在显著交互作用（交互作用P<0.05），尤其是在女性中。相比之下，在年龄、种族、教育水平、BMI、吸烟状况、饮酒、高血压、糖尿病和心绞痛之间未观察到显著交互作用（交互作用P>0.05）。RCS分析显示SIRI与CHD之间存在显著线性关系（非线性P>0.05），拐点为2.86。
我们的研究表明，系统炎症反应指数升高与冠心病风险较高相关。尤其是在女性中。
