Yamazaki Shun, Tominaga Kentaro, Watanabe Kotaro, Watanabe Makoto, Kondo Shuhei, Sakai Norihiro, Yoshida Tomoaki, Kojima Yuichi, Watanabe Yusuke, Kawata Yuzo, Kimura Naruhiro, Takahashi Kazuya, Sato Hiroki, Ikarashi Satoshi, Kamimura Hiroteru, Hayashi Kazunao, Terai Shuji
Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan.
Division of pathology, Graduate School of Medical and Dental Sciences, Niigata University, Japan.
Intern Med. 2025 Mar 22. doi: 10.2169/internalmedicine.5024-24.
Relapsing polychondritis (RP) is a rare, progressive, immune-mediated systemic inflammatory disease of unknown etiology characterized by recurrent inflammation of cartilaginous structures. Approximately 30% of RP cases are associated with autoimmune disease. However, co-occurrence of RP and Crohn's disease (CD) has rarely been reported. We herein report a case of coexisting RP, CD, and pyoderma gangrenosum that was successfully treated with adalimumab in combination with methotrexate. We believe that this case and literature review will facilitate the accurate and prompt diagnosis and treatment of RP combined with CD and various other complications.
复发性多软骨炎（RP）是一种罕见的、进行性的、病因不明的免疫介导的全身性炎症性疾病，其特征为软骨结构反复发炎。约30%的RP病例与自身免疫性疾病相关。然而，RP与克罗恩病（CD）同时出现的情况鲜有报道。我们在此报告一例同时存在RP、CD和坏疽性脓皮病的病例，该病例通过阿达木单抗联合甲氨蝶呤成功治愈。我们相信，该病例及文献综述将有助于准确、及时地诊断和治疗合并CD及各种其他并发症的RP。
