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Calorie restriction plugs lithocholic bile acid into the lysosomal AMPK pathway.

作者信息

Viollet Benoit

机构信息

Université Paris Cité, CNRS, Inserm, U1016, Institut Cochin, 24 rue du faubourg Saint Jacques, Paris 75014, France.

出版信息

Life Metab. 2025 Feb 11;4(2):loaf005. doi: 10.1093/lifemeta/loaf005. eCollection 2025 Apr.

DOI:10.1093/lifemeta/loaf005

PMID:40129483

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11932140/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44bc/11932140/c00b179b9167/loaf005_fig1.jpg

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Calorie restriction plugs lithocholic bile acid into the lysosomal AMPK pathway.

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Bile acid conjugation in the chimpanzee: effective sulfation of lithocholic acid.

Arch Toxicol. 1978 Apr 27;40(2):109-18. doi: 10.1007/BF01891965.

Comparison of biliary excretion and metabolism of lithocholic acid and its sulfate and glucuronide conjugates in rats.

Biochim Biophys Acta. 1989 Aug 8;1004(2):147-50. doi: 10.1016/0005-2760(89)90262-2.

Semiquantitative measurement of lithocholic acid compounds in bile from patients with gallstones, before and during treatment with chenodeoxycholic acid.

Scand J Gastroenterol. 1976;11(5):497-504.

Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity.

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Dietary restriction impacts health and lifespan of genetically diverse mice.

Nature. 2024 Oct;634(8034):684-692. doi: 10.1038/s41586-024-08026-3. Epub 2024 Oct 9.

AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension.

Cell Res. 2024 Nov;34(11):806-809. doi: 10.1038/s41422-024-01021-3. Epub 2024 Sep 19.

New insights into activation and function of the AMPK.

Nat Rev Mol Cell Biol. 2023 Apr;24(4):255-272. doi: 10.1038/s41580-022-00547-x. Epub 2022 Oct 31.

The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK.

Nat Metab. 2022 Oct;4(10):1369-1401. doi: 10.1038/s42255-022-00640-7. Epub 2022 Oct 10.

Low-dose metformin targets the lysosomal AMPK pathway through PEN2.

Nature. 2022 Mar;603(7899):159-165. doi: 10.1038/s41586-022-04431-8. Epub 2022 Feb 23.

Molecular mechanisms of dietary restriction promoting health and longevity.

Nat Rev Mol Cell Biol. 2022 Jan;23(1):56-73. doi: 10.1038/s41580-021-00411-4. Epub 2021 Sep 13.

Beyond weight loss: current perspectives on the impact of calorie restriction on healthspan and lifespan.

Expert Rev Endocrinol Metab. 2021 May;16(3):95-108. doi: 10.1080/17446651.2021.1922077. Epub 2021 May 7.

AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging.

Cell Metab. 2015 Jun 2;21(6):883-90. doi: 10.1016/j.cmet.2015.05.016.

AMPK at the nexus of energetics and aging.

Cell Metab. 2014 Jul 1;20(1):10-25. doi: 10.1016/j.cmet.2014.03.002. Epub 2014 Apr 10.

Extending healthy life span--from yeast to humans.

Science. 2010 Apr 16;328(5976):321-6. doi: 10.1126/science.1172539.

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相似文献

Calorie restriction plugs lithocholic bile acid into the lysosomal AMPK pathway.

Life Metab. 2025 Feb 11;4(2):loaf005. doi: 10.1093/lifemeta/loaf005. eCollection 2025 Apr.

Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing.

Nature. 2024 Dec 18. doi: 10.1038/s41586-024-08348-2.

Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions.

Oncotarget. 2018 Oct 9;9(79):34945-34971. doi: 10.18632/oncotarget.26188.

Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice.

Toxicol Appl Pharmacol. 2013 Dec 15;273(3):680-90. doi: 10.1016/j.taap.2013.10.020. Epub 2013 Oct 29.

Lithocholic acid phenocopies anti-ageing effects of calorie restriction.

Nature. 2024 Dec 18. doi: 10.1038/s41586-024-08329-5.

Bile acids extend longevity beyond calorie restriction.

Aging (Albany NY). 2010 Jul;2(7):385-6. doi: 10.18632/aging.100175.

Bile acid conjugation in the chimpanzee: effective sulfation of lithocholic acid.

Arch Toxicol. 1978 Apr 27;40(2):109-18. doi: 10.1007/BF01891965.

Comparison of biliary excretion and metabolism of lithocholic acid and its sulfate and glucuronide conjugates in rats.

Biochim Biophys Acta. 1989 Aug 8;1004(2):147-50. doi: 10.1016/0005-2760(89)90262-2.

Semiquantitative measurement of lithocholic acid compounds in bile from patients with gallstones, before and during treatment with chenodeoxycholic acid.

Scand J Gastroenterol. 1976;11(5):497-504.

Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity.

Drug Metab Rev. 2004 Oct;36(3-4):703-22. doi: 10.1081/dmr-200033475.

本文引用的文献

Dietary restriction impacts health and lifespan of genetically diverse mice.

Nature. 2024 Oct;634(8034):684-692. doi: 10.1038/s41586-024-08026-3. Epub 2024 Oct 9.

AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension.

Cell Res. 2024 Nov;34(11):806-809. doi: 10.1038/s41422-024-01021-3. Epub 2024 Sep 19.

New insights into activation and function of the AMPK.

Nat Rev Mol Cell Biol. 2023 Apr;24(4):255-272. doi: 10.1038/s41580-022-00547-x. Epub 2022 Oct 31.

The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK.

Nat Metab. 2022 Oct;4(10):1369-1401. doi: 10.1038/s42255-022-00640-7. Epub 2022 Oct 10.

Low-dose metformin targets the lysosomal AMPK pathway through PEN2.

Nature. 2022 Mar;603(7899):159-165. doi: 10.1038/s41586-022-04431-8. Epub 2022 Feb 23.

Molecular mechanisms of dietary restriction promoting health and longevity.

Nat Rev Mol Cell Biol. 2022 Jan;23(1):56-73. doi: 10.1038/s41580-021-00411-4. Epub 2021 Sep 13.

Beyond weight loss: current perspectives on the impact of calorie restriction on healthspan and lifespan.

Expert Rev Endocrinol Metab. 2021 May;16(3):95-108. doi: 10.1080/17446651.2021.1922077. Epub 2021 May 7.

AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging.

Cell Metab. 2015 Jun 2;21(6):883-90. doi: 10.1016/j.cmet.2015.05.016.

AMPK at the nexus of energetics and aging.

Cell Metab. 2014 Jul 1;20(1):10-25. doi: 10.1016/j.cmet.2014.03.002. Epub 2014 Apr 10.

Extending healthy life span--from yeast to humans.

Science. 2010 Apr 16;328(5976):321-6. doi: 10.1126/science.1172539.

Suppr超能文献

Calorie restriction plugs lithocholic bile acid into the lysosomal AMPK pathway.

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机构信息

出版信息

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