Ucar Ebubekir, Geetha Saroja Devi, Soundararajan Suganthi, Rishi Arvind, Savant Deepika
Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Greenvale, NY, USA.
Int J Surg Pathol. 2025 Oct;33(7):1634-1638. doi: 10.1177/10668969251327749. Epub 2025 Mar 25.
Mucosal Schwann cell hamartomas are relatively rare, incidental, benign neural tumors of the colonic mucosa. They are characterized by an ill-defined proliferation of spindle cells in the lamina propria, are thought to originate from Schwann cells, and hence are diffusely positive for S100 immunostain. Mucosal Schwann cell hamartomas differ from neurofibromas and ganglioneuromas due to the absence of syndromic associations. Differentiating mucosal Schwann cell hamartomas from other mesenchymal lesions of the colon is clinically important due to their benign course and lack of syndromic associations. Schwannoma, another neural tumor, commonly shows ancient changes, which are defined by large, irregular hyperchromatic nuclei without atypical mitosis or necrosis. Here, we report a rare lesion of colonic mucosal Schwann cell hamartoma with ancient changes (as described in schwannomas) to increase awareness of histologic variations associated with mucosal Schwann cell hamartomas.
黏膜施万细胞错构瘤是相对罕见的、偶然发现的结肠黏膜良性神经肿瘤。其特征是固有层中梭形细胞增殖不明确，被认为起源于施万细胞，因此S100免疫染色呈弥漫阳性。黏膜施万细胞错构瘤与神经纤维瘤和神经节神经瘤不同，因为不存在综合征关联。由于其良性病程且缺乏综合征关联，将黏膜施万细胞错构瘤与结肠的其他间充质病变区分开来在临床上很重要。另一种神经肿瘤——神经鞘瘤，通常表现出陈旧性改变，其定义为细胞核大、不规则、深染，无非典型有丝分裂或坏死。在此，我们报告一例罕见的伴有陈旧性改变（如神经鞘瘤中所描述）的结肠黏膜施万细胞错构瘤病变，以提高对与黏膜施万细胞错构瘤相关的组织学变异的认识。
