Pasquini Paola, Baiocchini Andrea, Falasca Laura, Annibali Dante, Gimbo Guido, Pace Francesco, Del Nonno Franca
Lab of Electron Microscopy, INMI-IRCCS L. Spallanzani, via Portuense 292, Rome 00149, Italy.
World J Gastroenterol. 2009 May 14;15(18):2287-9. doi: 10.3748/wjg.15.2287.
Schwannoma is a well-described, benign nerve sheath tumor of the soft tissue, but is rare in the gastrointestinal tract. Gastrointestinal schwannomas are often incidentally discovered as small polypoid intraluminal lesions. In this report, we describe the clinicopathologic and immunohistochemical features of a distinctive neural mucosal polyp composed of a diffuse cellular proliferation of uniform bland spindled cells in the lamina propria that entraps the colonic crypts. Immunohistochemical analysis revealed strong and diffuse positivity for the S-100 protein. To avoid confusion of these solitary colorectal polyps containing pure spindled Schwann cell proliferation in the lamina propria with neural lesions that have significant association with inherited syndromes, it is better to use the designation "mucosal Schwann hamartoma".
施万细胞瘤是一种已被充分描述的软组织良性神经鞘瘤，但在胃肠道中较为罕见。胃肠道施万细胞瘤常作为小的息肉样腔内病变偶然被发现。在本报告中，我们描述了一种独特的神经黏膜息肉的临床病理和免疫组化特征，该息肉由固有层中均匀一致的温和梭形细胞弥漫性细胞增生组成，包绕结肠隐窝。免疫组化分析显示S-100蛋白呈强弥漫阳性。为避免将这些固有层中含有纯梭形施万细胞增生的孤立性结直肠息肉与与遗传性综合征有显著关联的神经病变相混淆，最好使用“黏膜施万错构瘤”这一名称。
