Palaniswamy Saranya, Salah Soha, Přibylová Petra, Kukučka Petr, Laatio Liisa, Sieppi Elina, Kummu Maria, Rautio Arja, Myllynen Päivi, Abass Khaled
Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland; Arctic Health, Faculty of Medicine, University of Oulu, Oulu, Finland.
Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
Environ Toxicol Pharmacol. 2025 Apr;115:104679. doi: 10.1016/j.etap.2025.104679. Epub 2025 Mar 23.
Limited knowledge exists on persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs), in mother-child pairs from Northern Finland. This study examines plasma PCB and OCP concentrations and their determinants. Blood plasma concentrations of 13 PCBs and 6 OCPs were measured in mothers and in cord samples from the NUGEN birth cohort (N = 102, 2012-2014). Correlations between maternal and cord POPs were assessed using Spearman correlation, and linear regression identified factors influencing lipid-adjusted POPs. Maternal age and alcohol consumption during pregnancy were positively associated with PCBs and OCPs. Pre-pregnancy BMI and weight change during pregnancy were inversely associated with PCBs, but positively with p,p'-DDE in children. Increasing parity and smoking were associated with lower PCBs. Maternal fish consumption was associated with higher PCBs in children. Finnish pregnant women had lower PCBs and OCPs than other European populations. These findings inform exposure risk assessment and prevention strategies.
关于芬兰北部母婴群体中持久性有机污染物（POPs），包括多氯联苯（PCBs）和有机氯农药（OCPs）的知识有限。本研究检测了血浆中多氯联苯和有机氯农药的浓度及其决定因素。在NUGEN出生队列（2012 - 2014年，N = 102）的母亲和脐带样本中测量了13种多氯联苯和6种有机氯农药的血浆浓度。使用Spearman相关性评估母婴体内持久性有机污染物之间的相关性，并通过线性回归确定影响脂质调整后持久性有机污染物的因素。母亲年龄和孕期饮酒与多氯联苯和有机氯农药呈正相关。孕前体重指数和孕期体重变化与多氯联苯呈负相关，但与儿童体内的p,p'-二氯二苯二氯乙烯呈正相关。产次增加和吸烟与较低的多氯联苯相关。母亲食用鱼类与儿童体内较高的多氯联苯相关。芬兰孕妇体内的多氯联苯和有机氯农药含量低于其他欧洲人群。这些发现为暴露风险评估和预防策略提供了依据。
