XinHua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Children's Environmental Health, No. 1665 Kongjiang Road, Shanghai, 200092, China.
Sci Total Environ. 2011 Jul 15;409(16):2997-3002. doi: 10.1016/j.scitotenv.2011.04.040.
The use of most polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) has been restricted in China; however, their use remains a concern because of their adverse effects on human health, especially on fetuses and infants. To date, there is no data regarding the exposure levels of pregnant women to PCBs and OCPs in Shanghai. In order to evaluate PCB and OCP exposure levels and the contribution of dietary habits to these levels, we determined the concentrations of 8 PCBs and 14 OCPs in the umbilical cord blood serum of healthy pregnant women in Shanghai. Dietary habits of the pregnant women were obtained from a self-administered questionnaire. Results showed that p, p'-DDE, HCB and β-HCH were the major pollutants present in the serum samples; PCBs were detected in a few samples at low concentrations. Age, weight and body mass index before delivery were positively associated with serum levels of p, p'-DDE and β-HCH. Women and their husbands who had higher education levels, higher income levels, tended to have higher levels of p, p'-DDE and β-HCH. Spearman correlation analysis results suggested that consumption of foods such as milk, eggs, meat, fish, and shrimp may contribute to higher serum levels of p, p'-DDE and β-HCH. Furthermore, multiple linear regression analyses indicated that the age and educational levels of the pregnant women and their intake of fried/flamed food and shellfish were positively associated with β-HCH levels, and that the age and educational levels of the pregnant women and their intake of parity, beef, pork, mutton, and shrimp were positively associated with p, p'-DDE levels. This is the first study to investigate the exposure levels of pregnant women to PCBs and OCPs in Shanghai, and it should provide useful information for future related research.
多氯联苯（PCBs）和有机氯农药（OCPs）在中国的使用受到限制；然而，由于它们对人类健康，特别是对胎儿和婴儿的不良影响，它们的使用仍然令人担忧。迄今为止，尚无关于上海孕妇接触 PCBs 和 OCPs 的暴露水平的数据。为了评估 PCBs 和 OCPs 的暴露水平以及饮食习惯对这些水平的贡献，我们测定了上海健康孕妇脐带血血清中 8 种 PCBs 和 14 种 OCPs 的浓度。孕妇的饮食习惯是通过自我管理的问卷获得的。结果表明，p,p'-DDE、HCB 和β-HCH 是血清样品中存在的主要污染物；少数样本中检测到低浓度的 PCBs。分娩前的年龄、体重和体重指数与 p,p'-DDE 和β-HCH 的血清水平呈正相关。文化程度和收入水平较高的妇女及其丈夫，其 p,p'-DDE 和β-HCH 水平往往较高。Spearman 相关分析结果表明，食用牛奶、鸡蛋、肉类、鱼类和虾类等食物可能导致 p,p'-DDE 和β-HCH 的血清水平升高。此外，多元线性回归分析表明，孕妇的年龄和文化程度及其摄入的油炸/炒食物和贝类与β-HCH 水平呈正相关，而孕妇的年龄和文化程度及其摄入的产次、牛肉、猪肉、羊肉和虾与 p,p'-DDE 水平呈正相关。这是第一项研究上海孕妇接触 PCBs 和 OCPs 的暴露水平的研究，应该为未来的相关研究提供有用的信息。
