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对NovoSorb生物可降解临时基质在12个月期间使用情况的回顾,重点是通过一个简短病例系列说明游离皮瓣失败后的重建挽救。

A review of NovoSorb Biodegradable Temporising Matrix use over a 12-month period, with a focus on reconstructive salvage after free flap failure illustrated by a short case series.

作者信息

Tsang William, Saito Millan Lincoln, Williams Daniel, Cronin Drew, Gahankari Dilip, Sawhney Raja, Sheena Yezen

机构信息

Plastic and Reconstructive Surgery Department, Gold Coast University Hospital, Queensland, Australia.

Plastic and Reconstructive Surgery Department, Gold Coast University Hospital, Queensland, Australia; School of Medicine and Dentistry, Griffith University, Queensland, Australia.

出版信息

J Plast Reconstr Aesthet Surg. 2025 Apr;103:396-403. doi: 10.1016/j.bjps.2025.02.028. Epub 2025 Feb 24.

Abstract

We present a retrospective, cross-sectional review of 12 patients who underwent surgical reconstruction with NovoSorb® Biodegradable Temporising Matrix (BTM) over 1 year for trauma, cancer resection, necrotising fasciitis and chronic wounds. We report an overall success rate of BTM in 83% of cases. Three key cases are described in detail to show how BTM was successfully used as a means of reconstructive salvage after total or partial free flap failures for circumferential soft tissue defects that might otherwise have required a second free flap or limb amputation. The indications for BTM in non-burns wound closure are growing and our experience demonstrates it can provide a reliable 'salvage' reconstruction where traditional free flaps have failed and further tissue transfer is judged to have a poor risk-benefit ratio. We highlight BTM as an increasingly versatile tool in the armamentarium of reconstructive surgeons faced with challenging wounds including in the failed free flap setting and encourage further research on these advanced applications.

摘要

我们对12例患者进行了回顾性横断面研究,这些患者在1年多的时间里使用NovoSorb®生物可降解临时基质(BTM)进行了手术重建,病因包括创伤、癌症切除、坏死性筋膜炎和慢性伤口。我们报告BTM在83%的病例中总体成功率。详细描述了三个关键病例,以展示BTM如何成功用作全层或部分游离皮瓣失败后重建挽救的手段,这些病例为环形软组织缺损,否则可能需要进行第二次游离皮瓣或截肢。BTM在非烧伤伤口闭合中的应用指征正在增加,我们的经验表明,在传统游离皮瓣失败且进一步组织转移的风险效益比不佳时,它可以提供可靠的“挽救性”重建。我们强调BTM是重建外科医生面对具有挑战性伤口(包括游离皮瓣失败情况)时日益通用的工具,并鼓励对这些先进应用进行进一步研究。

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