阿尔茨海默病中针对脱髓鞘的性别偏向性靶点。
A sex-biased target against demyelination in Alzheimer's disease.
作者信息
Babcock Kelsey R, Yu Doudou, Webb Ashley E
机构信息
Graduate Program in Neuroscience, Brown University, Providence, RI 02912, USA.
Molecular Biology, Cell Biology, and Biochemistry Graduate Program, Brown University, Providence, RI 02912, USA; The Buck Institute for Research on Aging, Novato, CA 94945, USA.
出版信息
Trends Mol Med. 2025 Apr;31(4):304-306. doi: 10.1016/j.molmed.2025.03.004. Epub 2025 Mar 24.
Abstract
Aging and Alzheimer's disease (AD) exhibit sex differences in several biological processes, including demyelination. In a recent study, Lopez-Lee et al. uncover the contributions of sex chromosomes and gonadal hormones to sex differences in demyelination and identify Toll-like receptor 7 (TLR7) as a potential target to ameliorate tauopathy-induced demyelination in men.
摘要
衰老和阿尔茨海默病（AD）在包括脱髓鞘在内的多个生物学过程中表现出性别差异。在最近的一项研究中，洛佩斯 - 李等人揭示了性染色体和性腺激素对脱髓鞘性别差异的影响，并将Toll样受体7（TLR7）确定为改善男性tau蛋白病诱导的脱髓鞘的潜在靶点。
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2
drives sex differences in age- and Alzheimer's disease-related demyelination.导致与年龄和阿尔茨海默病相关的脱髓鞘作用存在性别差异。
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