Ren Yilin, Lin Hui, Guo Junnan, Su Xiaole, Wang Lihua, Qiao Xi
Department of Nephrology, Second Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.
Shanxi Kidney Disease Institute, Taiyuan, People's Republic of China.
Mol Cell Biochem. 2025 Mar 25. doi: 10.1007/s11010-025-05253-8.
Cardiac and kidney diseases are intimately linked through numerous pathophysiological pathways, frequently exerting reciprocal influences on one another. This interconnection often culminates in heightened morbidity and mortality rates within the clinical spectrum of cardiorenal syndrome (CRS). CRS is categorized into five types based on the primary organ involved and the chronicity of the condition. Each type of CRS encompasses a complex array of pathophysiological mechanisms. In recent years, the field of microRNAs (miRNAs) has risen to prominence, playing a crucial role in the pathogenesis of a multitude of diseases. By uncovering novel therapeutic targets through the study of miRNAs that influence the expression of the CRS genes, the prognostic outcomes for patients could be significantly improved. This article provides a comprehensive review, examining the pathophysiological underpinnings of CRS, miRNAs alterations and their associated mechanisms in various forms of CRS, as well as the potential of miRNAs in precision medicine and the use of miRNAs for the diagnosis of the disease.
心脏疾病和肾脏疾病通过众多病理生理途径紧密相连，常常相互施加影响。这种相互联系在心脏肾综合征（CRS）的临床范围内常常导致发病率和死亡率升高。CRS根据主要受累器官和病情的慢性程度分为五种类型。每种类型的CRS都包含一系列复杂的病理生理机制。近年来，微小RNA（miRNA）领域日益突出，在多种疾病的发病机制中发挥着关键作用。通过研究影响CRS基因表达的miRNA来发现新的治疗靶点，有望显著改善患者的预后。本文进行了全面综述，探讨了CRS的病理生理基础、不同形式CRS中miRNA的改变及其相关机制，以及miRNA在精准医学中的潜力和用于疾病诊断的情况。
