Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Basic Res Cardiol. 2023 May 4;118(1):16. doi: 10.1007/s00395-023-00986-3.
The number of "omics" approaches is continuously growing. Among others, epigenetics has appeared as an attractive area of investigation by the cardiovascular research community, notably considering its association with disease development. Complex diseases such as cardiovascular diseases have to be tackled using methods integrating different omics levels, so called "multi-omics" approaches. These approaches combine and co-analyze different levels of disease regulation. In this review, we present and discuss the role of epigenetic mechanisms in regulating gene expression and provide an integrated view of how these mechanisms are interlinked and regulate the development of cardiac disease, with a particular attention to heart failure. We focus on DNA, histone, and RNA modifications, and discuss the current methods and tools used for data integration and analysis. Enhancing the knowledge of these regulatory mechanisms may lead to novel therapeutic approaches and biomarkers for precision healthcare and improved clinical outcomes.
“组学”方法的数量正在不断增加。其中，表观遗传学作为一个有吸引力的研究领域出现在心血管研究界，特别是考虑到它与疾病发展的关联。复杂疾病，如心血管疾病，必须使用整合不同组学水平的方法来解决，即所谓的“多组学”方法。这些方法结合并共同分析疾病调节的不同水平。在这篇综述中，我们介绍并讨论了表观遗传机制在调节基因表达中的作用，并提供了一个综合的观点，说明这些机制是如何相互关联的，并调节心脏疾病的发展，特别关注心力衰竭。我们专注于 DNA、组蛋白和 RNA 修饰，并讨论了用于数据集成和分析的当前方法和工具。增强对这些调节机制的认识可能会导致新的治疗方法和用于精准医疗和改善临床结果的生物标志物。
