Cui Ying, Huang Qiang, Du Yitong, Wang Lin, Wang Shiya, Zhao Wenlu, Tuo Houzhen
Department of Neurology, Beijing Friendship Hospital, Capital Medical University, No. 95 YongAn Rd, Beijing, 100050, China.
BMC Geriatr. 2025 Mar 25;25(1):196. doi: 10.1186/s12877-025-05724-z.
Previous research has commonly regarded overactive bladder syndrome (OAB) and restless legs syndrome (RLS) as distinct disorders in terms of their underlying causes, clinical diagnosis, and treatment approaches. However, there is evidence of an overlap in the occurrence of these two conditions following cerebral infarction(CI). Specifically, restless bladder syndrome (RBS), a subtype of RLS, exhibits symptoms similar to those of OAB. Consequently, further investigation is warranted to better understand the relationship between these two disorders.
In this report, we present the cases of two patients who presented with both OAB following CI, along with RLS. Following administration of oral pramipexole, both nocturia and RLS exhibited prompt and efficient alleviation.
There may exist a shared pathological foundation between certain RLS cases and OAB. In instances where patients exhibit evident OAB symptoms following CI and concurrently experience RLS, it is advisable to prioritize the administration of dopaminergic agonists over M receptor inhibitors and β agonists. Furthermore, it is plausible that the RBS or a subset of RLS cases could potentially be classified as a form of OAB, although this correlation has yet to be definitively established.
既往研究通常认为,膀胱过度活动症(OAB)和不宁腿综合征(RLS)在潜在病因、临床诊断及治疗方法方面是不同的疾病。然而,有证据表明,脑梗死后(CI)这两种病症的发生存在重叠。具体而言,不宁腿综合征的一种亚型——不安腿综合征(RBS),表现出与膀胱过度活动症相似的症状。因此,有必要进一步研究以更好地理解这两种疾病之间的关系。
在本报告中,我们呈现了两名脑梗死后同时出现膀胱过度活动症和不宁腿综合征的患者病例。口服普拉克索后,夜尿症和不宁腿综合征均迅速且有效地得到缓解。
某些不宁腿综合征病例与膀胱过度活动症之间可能存在共同的病理基础。对于脑梗死后出现明显膀胱过度活动症症状且同时患有不宁腿综合征的患者,建议优先给予多巴胺能激动剂而非M受体抑制剂和β激动剂。此外,不安腿综合征或部分不宁腿综合征病例有可能被归类为膀胱过度活动症的一种形式,尽管这种关联尚未得到明确证实。