Lahham Elias Edward, Masri Huda Maher, Farhoud Zeina Adnan, Neiroukh Abrar Nidal, Ramahi Mahmoud, Awad Farah, Qubaja Marwan
Department of Radiation Oncology, Augusta Victoria Hospital, Martin Buber Jerusalem 9119101, East Jerusalem, Palestinian Authority, Palestine.
Faculty of Medicine, Al-Quds University, Main Campus, Abu Dis, PO Box 89, Palestine.
J Surg Case Rep. 2025 Mar 25;2025(3):rjaf148. doi: 10.1093/jscr/rjaf148. eCollection 2025 Mar.
Pulmonary adenocarcinoma, the most common subtype of non-small cell lung cancer, frequently metastasizes to the brain, liver, bones, and adrenal glands. However, breast metastases are exceedingly rare, accounting for 0.2%-1.3% of extramammary metastases, with only 0.1% of secondary breast malignancies originating from the lung. This case report presents a 56-year-old non-smoking male who presented with a unilateral retro-areolar breast lump. Further evaluation revealed ipsilateral axillary lymphadenopathy, and diagnostic biopsy and immunohistochemistry confirmed the lung origin of the breast lesion. This study emphasizes the significance of taking into account breast metastasis in the differential diagnosis of breast lesions in male patients, particularly those with a known primary malignancy. It highlights the need to recognize breast lumps as a potential presentation of secondary breast malignancy.
肺腺癌是非小细胞肺癌最常见的亚型，常转移至脑、肝、骨和肾上腺。然而，肺腺癌转移至乳腺极为罕见，占乳腺外转移的0.2%-1.3%，仅有0.1%的继发性乳腺恶性肿瘤起源于肺。本病例报告介绍了一名56岁的不吸烟男性，其表现为单侧乳晕后乳腺肿块。进一步评估发现同侧腋窝淋巴结肿大，诊断性活检及免疫组化证实该乳腺病变起源于肺。本研究强调在男性患者乳腺病变的鉴别诊断中，尤其是那些已知原发性恶性肿瘤的患者，考虑乳腺转移的重要性。它突出了将乳腺肿块识别为继发性乳腺恶性肿瘤潜在表现的必要性。
