Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
J Surg Oncol. 2010 Feb 1;101(2):137-40. doi: 10.1002/jso.21453.
Breast metastasis from extramammary neoplasm is rare. We present the cases of metastasis to the breast after review of results in one institute and we want to show the difference of previous report.
The surgical and pathology databases of Samsung Medical Center from November 1994 to March 2009 were investigated to identify all patients with a diagnosis of metastasis to the breast.
Thirty-three patients with breast metastases from extramammary neoplasm were studied. Gastric carcinoma was most common metastatic origin in this study. There were four cases with microcalcifications in their metastatic lesions. This is the first report of microcalcification of metastatic lesions to the breast from hepatocellular carcinoma and gastric cancer.
Pathologic examination and considering known clinical history may be helpful to differentiate the primary breast cancer and metastatic cancer. Metastasis to the breast from an extramammary neoplasm usually indicates disseminated metastatic disease and a poor prognosis. An accurate diagnosis of breast metastases, differentiating primary from metastatic breast carcinoma, is important for proper management.
来自于非乳腺的恶性肿瘤的乳腺转移较为罕见。我们通过对一家医院的研究结果进行回顾，报道了此类病例，并展示了与既往报道的不同之处。
我们对三星医疗中心（Samsung Medical Center）1994 年 11 月至 2009 年 3 月的外科和病理数据库进行了调查，以确定所有诊断为乳腺转移的患者。
我们研究了 33 例来自非乳腺恶性肿瘤的乳腺转移患者。在本研究中，胃癌是最常见的转移性来源。其中有 4 例转移性病变中有微钙化。这是转移性肝癌和胃癌累及乳腺出现微钙化的首例报道。
病理检查和考虑已知的临床病史可能有助于鉴别原发性乳腺癌和转移性乳腺癌。来自于非乳腺恶性肿瘤的乳腺转移通常提示存在广泛转移的疾病和不良预后。准确诊断乳腺转移，区分原发性和转移性乳腺癌，对于恰当的治疗管理非常重要。
