Adams Simon T, Cox Julie, Rao G Sam
University Hospital of North Durham North Road, Durham, County Durham DH1 5TW UK.
J Med Case Rep. 2009 Mar 10;3:6442. doi: 10.1186/1752-1947-3-6442.
Silicone lymphadenopathy is a rare but recognised complication of procedures involving the use of silicone. It has a poorly understood mechanism but is thought to occur following the transportation of silicone particles from silicone-containing prostheses to lymph nodes by macrophages.
We report of a case involving a 35-year-old woman who presented to the breast clinic with a breast lump and altered sensation below her left nipple 5 years after bilateral cosmetic breast augmentations. A small lump was detected inferior to the nipple but clinical examination and initial ultrasound investigation showed both implants to be intact. However, mammography and magnetic resonance imaging of both breasts revealed both intracapsular and extracapsular rupture of the left breast prosthesis. The patient went on to develop a flu-like illness and tender lumps in the left axilla and right mastoid regions. An excision biopsy of the left axillary lesion and replacement of the ruptured implant was performed. Subsequent histological analysis showed that the axillary lump was a lymph node containing large amounts of silicone.
The exclusion of malignancy remains the priority when dealing with lumps in the breast or axilla. Silicone lymphadenopathy should however be considered as a differential diagnosis in patients in whom silicone prostheses are present.
硅胶性淋巴结病是使用硅胶的手术中一种罕见但已被认识到的并发症。其发病机制尚不清楚,但被认为是巨噬细胞将硅胶颗粒从含硅胶假体转运至淋巴结后发生的。
我们报告一例35岁女性病例,该患者在双侧美容性隆乳术后5年因乳房肿块及左侧乳头下方感觉改变就诊于乳腺科。在乳头下方发现一个小肿块,但临床检查和初步超声检查显示两个植入物均完整。然而,双侧乳房的乳腺X线摄影和磁共振成像显示左侧乳房假体出现囊内和囊外破裂。患者继而出现类似流感的疾病,左侧腋窝和右侧乳突区出现压痛性肿块。对左侧腋窝病变进行了切除活检并更换了破裂的植入物。随后的组织学分析表明,腋窝肿块是一个含有大量硅胶的淋巴结。
处理乳房或腋窝肿块时,排除恶性肿瘤仍然是首要任务。然而,对于存在硅胶假体的患者,应考虑将硅胶性淋巴结病作为鉴别诊断。