Jaros Joanna, Ahuja Kripa, Lio Peter
Dr. Jaros is with the Department of Dermatology at Cook County Hospital and Health System in Chicago, Illinois.
Ms. Ahuja is with Eastern Virginia Medical School in Norfolk, Virginia.
J Clin Aesthet Dermatol. 2025 Mar;18(3):15-20.
Eosinophilic esophagitis (EoE) and atopic dermatitis (AD) are two known and sometimes comorbid type 2 helper cell-mediated diseases. EoE shares clinical features, immunologic pathways, susceptibility loci, and risk with atopic conditions including food allergies (food allergies), asthma, allergic rhinitis (AR), and AD. These conditions share an impaired immunological response against a range of antigens or allergens, leading to CD4+ Th2 differentiation and overproduction of immunoglobulin E (IgE). The emerging coexistence of EoE and AD presents a compelling area of study. Both diseases manifest on stratified squamous epithelium along the skin-gut continuum and have overlapping treatment algorithms that include avoidance of triggers, topical steroids, and dupilumab. This narrative review highlights the clinical and immunologic nuances underlying these two conditions and sheds light on potential new research and therapeutic avenues.
嗜酸性食管炎（EoE）和特应性皮炎（AD）是两种已知的、有时会合并出现的2型辅助性T细胞介导的疾病。EoE与特应性疾病（包括食物过敏、哮喘、过敏性鼻炎（AR）和AD）具有共同的临床特征、免疫途径、易感基因座和风险。这些疾病对一系列抗原或过敏原的免疫反应受损，导致CD4 + Th2细胞分化和免疫球蛋白E（IgE）过度产生。EoE和AD同时出现这一现象成为了一个引人注目的研究领域。这两种疾病均表现在皮肤-肠道连续体的复层鳞状上皮上，并且具有重叠的治疗方案，包括避免触发因素、局部使用类固醇和度普利尤单抗。这篇叙述性综述强调了这两种疾病潜在的临床和免疫细微差别，并阐明了潜在的新研究和治疗途径。
