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本文引用的文献

1
Microelement strontium and human health: comprehensive analysis of the role in inflammation and non-communicable diseases (NCDs).微量元素锶与人类健康:对其在炎症和非传染性疾病(NCDs)中作用的综合分析
Front Chem. 2024 Mar 28;12:1367395. doi: 10.3389/fchem.2024.1367395. eCollection 2024.
2
Modulation of Skin Inflammatory Responses by Aluminum Adjuvant.铝佐剂对皮肤炎症反应的调节作用。
Pharmaceutics. 2023 Feb 8;15(2):576. doi: 10.3390/pharmaceutics15020576.
3
Itch in Hidradenitis Suppurativa/Acne Inversa: A Systematic Review.化脓性汗腺炎/反向性痤疮中的瘙痒:一项系统评价
J Clin Med. 2022 Jun 30;11(13):3813. doi: 10.3390/jcm11133813.
4
Hidradenitis suppurativa: an update on epidemiology, phenotypes, diagnosis, pathogenesis, comorbidities and quality of life.化脓性汗腺炎:流行病学、表型、诊断、发病机制、合并症及生活质量的最新进展
J Eur Acad Dermatol Venereol. 2021 Jan;35(1):50-61. doi: 10.1111/jdv.16677. Epub 2020 Jul 16.
5
Topical, systemic and biologic therapies in hidradenitis suppurativa: pathogenic insights by examining therapeutic mechanisms.化脓性汗腺炎的局部、全身及生物治疗:通过研究治疗机制获得的发病机制见解
Ther Adv Chronic Dis. 2019 Mar 1;10:2040622319830646. doi: 10.1177/2040622319830646. eCollection 2019.
6
Assessing Pruritus in Hidradenitis Suppurativa: A Cross-Sectional Study.评估化脓性汗腺炎的瘙痒:一项横断面研究。
Am J Clin Dermatol. 2017 Oct;18(5):687-695. doi: 10.1007/s40257-017-0280-2.
7
Hidradenitis suppurativa: Epidemiology and scope of the problem.化脓性汗腺炎:流行病学和问题范围。
J Am Acad Dermatol. 2015 Nov;73(5 Suppl 1):S4-7. doi: 10.1016/j.jaad.2015.07.052.
8
Reduced burning and stinging associated with topical application of lactic acid 10% with strontium versus ammonium lactate 12%.与10%乳酸与锶联合局部应用相比,12%乳酸铵局部应用时灼痛和刺痛减轻。
Cutis. 2013 May;91(5):260-2.
9
Clinical practice. Chronic pruritus.临床实践。慢性瘙痒。
N Engl J Med. 2013 Apr 25;368(17):1625-34. doi: 10.1056/NEJMcp1208814.
10
Understanding the pathophysiology of itch.理解瘙痒的病理生理学。
Dermatol Ther. 2013 Mar-Apr;26(2):84-91. doi: 10.1111/dth.12025.

锶乳膏减轻化脓性汗腺炎瘙痒的疗效

Efficacy of Strontium Cream in Alleviating Pruritus in Hidradenitis Suppurativa.

作者信息

Walker Rubi, Brooks Brindley, Daveluy Steven

机构信息

Ms. Walker is with the Wayne State University School of Medicine in Detroit, Michigan.

Ms. Brooks is with HS Connect in Puyallup, Washington.

出版信息

J Clin Aesthet Dermatol. 2025 Mar;18(3):12-14.

PMID:40135181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11932098/
Abstract

OBJECTIVE

Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition with limited treatment options and a significant impact on quality of life. This prospective, open-label, real-world study aimed to evaluate the efficacy of strontium cream in alleviating pruritus in HS.

METHODS

Fifty participants completed baseline and one-week post-intervention surveys. Pruritus was assessed using a numeric severity scale and a qualitative survey on overall itch reduction.

RESULTS

Statistical analysis revealed a significant reduction in itching symptoms post-intervention, with mean itch scores decreasing from 3.80±0.90 at baseline to 2.28±1.50 post-intervention (<0.001). Participant feedback also indicated overall satisfaction, with 84 percent of participants willing to recommend the cream to other HS patients.

LIMITATIONS

The study relied on self-reported data, which introduces subjectivity, and the absence of a control group limits causal inference.

CONCLUSION

Strontium cream demonstrates promise as a therapeutic option for managing pruritus in HS, warranting further research.

摘要

目的

化脓性汗腺炎(HS)是一种慢性炎症性皮肤病,治疗选择有限,对生活质量有重大影响。这项前瞻性、开放标签的真实世界研究旨在评估锶乳膏缓解HS瘙痒的疗效。

方法

50名参与者完成了基线调查和干预后一周的调查。使用数字严重程度量表和关于总体瘙痒减轻情况的定性调查来评估瘙痒。

结果

统计分析显示,干预后瘙痒症状显著减轻,平均瘙痒评分从基线时的3.80±0.90降至干预后的2.28±1.50(<0.001)。参与者的反馈也表明总体满意度较高,84%的参与者愿意向其他HS患者推荐该乳膏。

局限性

该研究依赖自我报告的数据,这引入了主观性,且缺乏对照组限制了因果推断。

结论

锶乳膏有望成为治疗HS瘙痒的一种治疗选择,值得进一步研究。