Abdullahi Idris Nasir, Trabelsi Islem
Department of Medical Laboratory Science, Faculty of Allied Health Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria.
Laboratoire Bioressources, Environnement et Biotechnologie (LR22ES04), Institut Supérieur des Sciences Biologiques Appliquées de Tunis, Université de Tunis El Manar, Tunis, Tunisie.
Avian Pathol. 2025 Oct;54(5):577-591. doi: 10.1080/03079457.2025.2485106. Epub 2025 Apr 30.
Birds harbour and as gut commensals but could acquire and transmit high-priority strains. Following the PRISMA guidelines, eligible studies that reported the antimicrobial resistance (AMR) profiles of and from gut samples of food-producing (FPBs) and wild birds (WBs) published from 2005-2024 were screened from major bibliographic databases. Random-effect models were used to determine the pooled prevalences (PPs) of vancomycin (VAN), ampicillin (AMP), and linezolid (LZD) resistant and from non-duplicated gut samples of FPBs and WBs. Of the 36 eligible studies, the overall PP of VAN- and VAN- were 1.8% and 0.7%, respectively. AMP- and AMP- were 1.6% and 0.6%, respectively. LZD- and LZD- were 1% and 0.8%, respectively. Subgroup analyses revealed significant temporal variations in the PPs of VAN- ( < 0.05). FPBs had significantly higher PPs of VAN, AMP and LZD and than WBs ( < 0.05). Healthcare-associated -carrying lineages from WBs (ST16, ST17, ST18, and ST412) and -carrying lineages (ST32, ST59, ST330) from FPBs were identified. In FPBs, Egypt had the highest PP of VAN- (11.9%) and LZD- (2.8%). Conversely, the USA had the highest PP of VAN- in WBs (2.4%). A higher frequency of vancomycin- than linezolid-resistant strains exists, and VAN- are disproportionately distributed based on bird species, year of study, and country, indicating varied selection pressure. Significantly higher prevalence of VAN- than VAN- was found, highlighting the higher capacity of to acquire ampicillin and vancomycin resistance in birds. Vancomycin, ampicillin, and linezolid resistance in and are considered high-priority public health concerns.This is a meta-analysis of high-priority and from gut samples of birds.Food-producing birds had significantly higher frequency of priority and than wild birds.Vancomycin resistance in and exists more frequently than linezolid resistance. has a higher capacity to acquire ampicillin and vancomycin resistance than .Genetically related human-adapted vancomycin- and linezolid-resistant strains were identified in food-producing and wild birds.
鸟类作为肠道共生菌携带……，但可能获得并传播高优先级菌株。遵循PRISMA指南，从主要文献数据库中筛选出2005年至2024年发表的、报告了来自产食鸟类（FPBs）和野生鸟类（WBs）肠道样本中……的抗菌药物耐药性（AMR）概况的合格研究。采用随机效应模型确定来自FPBs和WBs非重复肠道样本中耐万古霉素（VAN）、氨苄西林（AMP）和利奈唑胺（LZD）的……的合并患病率（PPs）。在36项合格研究中，VAN耐药和VAN耐药的总体PP分别为1.8%和0.7%。AMP耐药和AMP耐药的分别为1.6%和0.6%。LZD耐药和LZD耐药的分别为1%和0.8%。亚组分析显示VAN耐药的PP存在显著的时间变化（P<0.05）。FPBs中VAN、AMP和LZD耐药的PP显著高于WBs（P<0.05）。鉴定出了来自WBs的与医疗保健相关的携带……的谱系（ST16、ST17、ST18和ST412）以及来自FPBs的携带……的谱系（ST32、ST59、ST330）。在FPBs中，埃及VAN耐药的PP最高（11.9%），LZD耐药的PP最高（2.8%）。相反，美国WBs中VAN耐药的PP最高（2.4%）。耐万古霉素菌株的频率高于耐利奈唑胺菌株，并且VAN耐药菌株根据鸟类物种、研究年份和国家的分布不成比例，表明选择压力不同。发现VAN耐药的患病率显著高于VAN耐药，突出了……在鸟类中获得氨苄西林和万古霉素耐药性的能力更强。万古霉素、氨苄西林和利奈唑胺在……中的耐药性被视为高优先级的公共卫生问题。这是一项对来自鸟类肠道样本的高优先级……的荟萃分析。产食鸟类中优先级……的频率显著高于野生鸟类。……中耐万古霉素的情况比耐利奈唑胺更常见。……获得氨苄西林和万古霉素耐药性的能力比……更强。在产食鸟类和野生鸟类中鉴定出了与人类适应的耐万古霉素和耐利奈唑胺基因相关的菌株。
