Li Xudong, Lou Chun, Ren He, Cui Lina, Chen Kexin
Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, China.
Hum Vaccin Immunother. 2025 Dec;21(1):2483022. doi: 10.1080/21645515.2025.2483022. Epub 2025 Mar 26.
Immunity has vital research value and promising applications in triple-negative breast cancer (TNBC). Nevertheless, few bibliometric analyses have systematically investigated this area. This study aimed to comprehensively review the collaboration and impact of countries, institutions, authors, and journals on the role of immunity in TNBC from a bibliometric perspective, evaluate the keyword co-occurrence of the knowledge structure, and identify hot trends and emerging topics. Articles and reviews related to immunity in TNBC were retrieved from the Web of Science core collection using subject search. A bibliometric study was conducted primarily using CiteSpace and VOSviewer. A total of 3,104 articles and reviews were included from January 1, 2014, through December 31, 2024. The number of articles on immunization in TNBC is rising. These publications are mainly from 415 institutions in 82 countries, led by China and the USA. Among these publications, published the most papers, while was co-cited the most. The most productive journals focused on molecular biology, biological immunology, and clinical medicine. Furthermore, co-citation analysis revealed that tumor microenvironment, biomarkers, and immune checkpoint inhibitors are current and developing research areas. The keywords and are also likely to be new trends and focal points for future research. This study adopted bibliometric and visualization methods to provide a comprehensive review of the research on immunization in TNBC. This article will help researchers better understand the dynamic evolution of the role of immunity in TNBC and identify areas for future research.
免疫在三阴性乳腺癌（TNBC）中具有重要的研究价值和广阔的应用前景。然而，很少有文献计量分析系统地研究这一领域。本研究旨在从文献计量学角度全面综述各国、机构、作者和期刊在免疫在TNBC中的作用方面的合作与影响，评估知识结构的关键词共现情况，识别热点趋势和新兴主题。通过主题检索从Web of Science核心合集中检索与TNBC免疫相关 的文章和综述。主要使用CiteSpace和VOSviewer进行文献计量学研究。纳入了2014年1月1日至2024年12月31日期间的3104篇文章和综述。TNBC免疫相关文章数量正在上升。这些出版物主要来自82个国家的415个机构，以中国和美国为首。在这些出版物中， 发表的论文最多，而 被共引次数最多。产出最多的期刊集中在分子生物学、生物免疫学和临床医学领域。此外，共引分析表明肿瘤微环境、生物标志物和免疫检查点抑制剂是当前和正在发展的研究领域。关键词 和 也可能是未来研究的新趋势和重点。本研究采用文献计量学和可视化方法对TNBC免疫研究进行了全面综述。本文将帮助研究人员更好地了解免疫在TNBC中作用的动态演变，并确定未来的研究领域。
