Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical University.
Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Chongqing Medical University.
Int J Surg. 2024 Aug 1;110(8):4976-4992. doi: 10.1097/JS9.0000000000001586.
Triple-negative breast cancer (TNBC) is a highly aggressive type of breast cancer with poor prognosis, and neoadjuvant therapy (NAT) has emerged as an important component in managing advanced-stage patients by providing surgical opportunities and improving survival outcomes. A search of publications on NAT for TNBC from 2002 to 2023 was conducted through the Web of Science core collection. A comprehensive bibliometric analysis was conducted on the data using CiteSpace, VOSviewer, and Bibliometrix. The analysis revealed a continuous and steady growth in the number of articles published in this field over the past 20 years. The United States has made significant contributions to this field, with The University of Texas MD Anderson Cancer Center publishing the most articles. Loibl, S. from Germany was found to be the most published author with 54 articles. Analysis of the journals showed that the Journal of Clinical Oncology is the most cited journal. Combined with the keyword co-occurrence analysis and clustering analysis, current research topic focuses on treatment regimens and disease prognosis. Dual-map overlay of the journals indicates that the research trend is gradually shifting from molecular biology and genetics to immunology and clinical research. Combination therapy, including immunotherapy, may be the future direction for NAT treatment of TNBC. Overall, this study provides valuable insights into the current research status, latest advancements, and emerging development trend of NAT for TNBC.
三阴性乳腺癌(TNBC)是一种侵袭性强、预后差的乳腺癌,新辅助治疗(NAT)已成为晚期患者治疗的重要组成部分,通过提供手术机会和改善生存结果。通过 Web of Science 核心合集对 2002 年至 2023 年关于 TNBC 的 NAT 的出版物进行了检索。使用 CiteSpace、VOSviewer 和 Bibliometrix 对数据进行了全面的文献计量分析。分析显示,过去 20 年来,该领域发表的文章数量持续稳定增长。美国在该领域做出了重大贡献,其中德克萨斯大学 MD 安德森癌症中心发表的文章最多。德国的 Loibl,S. 是发表文章最多的作者,有 54 篇文章。对期刊的分析表明,《临床肿瘤学杂志》是被引最多的期刊。结合关键词共现分析和聚类分析,当前的研究主题集中在治疗方案和疾病预后上。期刊的双图叠加表明,研究趋势正在逐渐从分子生物学和遗传学转向免疫学和临床研究。联合治疗,包括免疫疗法,可能是 TNBC 的 NAT 治疗的未来方向。总的来说,这项研究为了解 TNBC 的 NAT 的当前研究状况、最新进展和新兴发展趋势提供了有价值的见解。
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