Murasugi Ryo, Kawanabe Hitoshi, Murakami Ayano, Fukuya Yasuhiko, Imura Hideto, Natsume Nagato, Sato Ken, Mitachi Seiko, Fukui Kazunori
Division of Orthodontics and Dentofacial Orthopedics, Department of Oral Growth and Development, Ohu University School of Dentistry, Fukushima 963-8041, Japan.
Department of Dentofacial Orthopedics, Graduate School of Dentistry, Ohu University School of Dentistry, Fukushima 963-8041, Japan.
Diseases. 2025 Feb 21;13(3):64. doi: 10.3390/diseases13030064.
Pediatric sleep-disordered breathing (SDB) can cause behavioral and cognitive problems and even physical growth impairment, but it is often under-recognized. Cleft lip and/or palate (CLP) is a common birth defect and known risk factor for SDB. In this study, we examined the sleep breathing status in infants with unilateral CLP (UCLP) before and after cheiloplasty and palatoplasty. This prospective before-after study included infants with UCLP who could undergo the sleep breathing test and sleep for >1 h. Their sleep breathing status was assessed using a fiber-based sleep apnea sensor (Fiber-Based Sleep Apnea Syndrome Sensor) on the day before surgery and 1-3 d after surgery. We calculated and compared the pre- and postoperative respiratory disturbance index (RDI) following the criteria proposed by the American Academy of Sleep Medicine. The mean RDI significantly improved both after cheiloplasty (from 7.5 ± 4.6 to 2.7 ± 1.4 events/h, = 0.007) and after palatoplasty (from 4.4 ± 2.3 to 1.7 ± 0.4 events/h, = 0.010). Cheiloplasty and palatoplasty could improve SDB and reduce its adverse effects on the physical growth and development of infants with UCLP.
小儿睡眠呼吸障碍（SDB）可导致行为和认知问题，甚至身体发育受损，但往往未得到充分认识。唇裂和/或腭裂（CLP）是一种常见的出生缺陷，也是SDB的已知危险因素。在本研究中，我们检查了单侧唇裂（UCLP）婴儿在唇裂修复术和腭裂修复术前及术后的睡眠呼吸状况。这项前瞻性前后对照研究纳入了能够接受睡眠呼吸测试且睡眠超过1小时的UCLP婴儿。在手术前一天和手术后1 - 3天，使用基于光纤的睡眠呼吸暂停传感器（基于光纤的睡眠呼吸暂停综合征传感器）评估他们的睡眠呼吸状况。我们根据美国睡眠医学学会提出的标准计算并比较了术前和术后的呼吸紊乱指数（RDI）。唇裂修复术后（从7.5±4.6次/小时降至2.7±1.4次/小时，P = 0.007）和腭裂修复术后（从4.4±2.3次/小时降至1.7±0.4次/小时，P = 0.010），平均RDI均显著改善。唇裂修复术和腭裂修复术可改善UCLP婴儿的SDB，并减少其对身体生长发育的不良影响。
