Ye Huijun, Zhang Ruijuan, Zhang Chunye, Xia Yujie, Jin Lihua
The Second Affiliated Hospital of Zhejiang Chinese Medical University, No.318 Chaowang Road, Hangzhou, 310005, Zhejiang, China.
Center for Peak of Excellence on Biological Science and Food Engineering, National University of Singapore (Suzhou) Research Institute, Suzhou, 215004, Jiangsu, China.
Asian J Surg. 2024 Aug 30. doi: 10.1016/j.asjsur.2024.08.100.
Hyaluronic acid (HA) is a natural glycosaminoglycan found in the human body, particularly in the extracellular matrix of body fluids and tissues. It plays a critical role in cellular processes of living organisms by maintaining tissue hydration, cell proliferation, differentiation, and inflammatory response. HA exhibits significant biological activity in skin care, aesthetic anti-aging, medical orthopedic repair, gynecological cancer monitoring, and other pathological conditions. Due to its exceptional biocompatibility, biodegradability, lack of toxicity, non-immunogenicity, and its capacity to bond with other substances, various HA-based biomedical products like hydrogels, microneedles, and microspheres have been developed. These innovations have also been applied in various medical and health fields, such as bone and tissue regeneration, gels for medical aesthetic fillers, and gynecology-related cancer treatment, utilizing the HA drug delivery pathway. The interest in HA and its products is increasing due to their biological functions. Therefore, this review aimed to summarize the biological properties of HA and to focus on its applications in the bone tissue engineering and healthcare, for HA has some practical applications of HA-based complexes in biomedical materials, tissue repair, medical aesthetics, and gynecology. Through this review, we seek to offer theoretical research assistance for the development of HA-based bioproducts in the healthcare domain and provide innovative insights for human health.
透明质酸（HA）是一种存在于人体中的天然糖胺聚糖，尤其存在于体液和组织的细胞外基质中。它通过维持组织水合作用、细胞增殖、分化和炎症反应，在生物体的细胞过程中发挥关键作用。HA在皮肤护理、美容抗衰、医学骨科修复、妇科癌症监测及其他病理状况中展现出显著的生物活性。由于其卓越的生物相容性、生物降解性、无毒性、非免疫原性以及与其他物质结合的能力，已开发出各种基于HA的生物医学产品，如水凝胶、微针和微球。这些创新成果也已应用于各个医疗卫生领域，如骨与组织再生、用于医学美容填充的凝胶以及与妇科相关的癌症治疗，利用了HA药物递送途径。由于其生物学功能，人们对HA及其产品的兴趣与日俱增。因此，本综述旨在总结HA的生物学特性，并聚焦于其在骨组织工程和医疗保健中的应用，因为基于HA的复合物在生物医学材料、组织修复、医学美容和妇科方面具有一些实际应用。通过本综述，我们旨在为医疗保健领域基于HA的生物产品开发提供理论研究支持，并为人类健康提供创新性见解。
