新冠疫情期间肠道真菌群落的变化
Gut Mycobiome Changes During COVID-19 Disease.
作者信息
Krivonos Danil V, Fedorov Dmitry E, Klimina Ksenia M, Veselovsky Vladimir A, Kovalchuk Svetlana N, Pavlenko Alexander V, Yanushevich Oleg O, Andreev Dmitry N, Sokolov Filipp S, Fomenko Aleksey K, Devkota Mikhail K, Andreev Nikolai G, Zaborovsky Andrey V, Tsaregorodtsev Sergei V, Evdokimov Vladimir V, Krikheli Natella I, Bely Petr A, Levchenko Oleg V, Maev Igor V, Govorun Vadim M, Ilina Elena N
机构信息
Research Institute for Systems Biology and Medicine (RISBM), 18, Nauchniy Proezd, 117246 Moscow, Russia.
Department of Molecular and Translational Medicine, Moscow Institute of Physics and Technology, State University, 141700 Dolgoprudny, Russia.
出版信息
J Fungi (Basel). 2025 Mar 3;11(3):194. doi: 10.3390/jof11030194.
The majority of metagenomic studies are based on the study of bacterial biota. At the same time, the COVID-19 pandemic has prompted interest in the study of both individual fungal pathogens and fungal communities (i.e., the mycobiome) as a whole. Here, in this work, we investigated the human gut mycobiome during COVID-19. Stool samples were collected from patients at two time points: at the time of admission to the hospital (the first time point) and at the time of discharge from the hospital (the second time point). The results of this study revealed that sp. is more represented in a group of patients with COVID-19. Therefore, sp. is elevated in patients at the time of admission to the hospital and underestimated at the time of discharge. Additionally, the influence of factors associated with the diversity of fungal gut microbiota was separately studied, including disease severity and age factors.
大多数宏基因组学研究基于对细菌生物群的研究。与此同时，新冠疫情激发了人们对单个真菌病原体以及整个真菌群落（即真菌微生物组）研究的兴趣。在此项工作中，我们研究了新冠疫情期间的人类肠道真菌微生物组。在两个时间点采集了患者的粪便样本：入院时（第一个时间点）和出院时（第二个时间点）。这项研究的结果显示， 种在新冠患者群体中表现更为突出。因此， 种在患者入院时升高，而出院时被低估。此外，还分别研究了与肠道真菌微生物群多样性相关的因素的影响，包括疾病严重程度和年龄因素。
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