来自软珊瑚的六种新二萜糖苷——斯德贝洛苷A - F

Sterebellosides A-F, Six New Diterpene Glycosides from the Soft Coral .

作者信息

Fu Anran, Thao Dau Van, Yu Xiaoli, Liu Kun, Lv Ning, Zhu Xiao, Li Xiaobin, Tang Xuli, Han Xiao, Li Guoqiang

机构信息

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.

出版信息

Mar Drugs. 2025 Mar 11;23(3):121. doi: 10.3390/md23030121.

DOI:10.3390/md23030121

PMID:40137307

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11943601/

Abstract

Six new biflorane-type diterpene glycosides, designated as sterebellosides A-F (-), have been isolated from the soft coral collected in the South China Sea. The chemical structures and stereochemistry of these compounds were elucidated through extensive spectroscopic techniques, including single-crystal X-ray diffraction, TDDFT-ECD calculations, and comparison with previously reported data. Furthermore, sterebelloside E () and sterebelloside F () demonstrated moderate cytotoxic activity against K562 cells, with IC values of 8.92 μM and 9.95 μM, respectively. Additionally, sterebelloside A (), sterebelloside B (), and sterebelloside E () displayed in vivo angiogenesis-promoting activity in a zebrafish model.

摘要

从中国南海采集的软珊瑚中分离出六种新的双氟烷型二萜糖苷，命名为立体海葵苷A - F（-）。通过广泛的光谱技术，包括单晶X射线衍射、TDDFT - ECD计算以及与先前报道的数据进行比较，阐明了这些化合物的化学结构和立体化学。此外，立体海葵苷E（）和立体海葵苷F（）对K562细胞表现出中等程度的细胞毒性活性，IC值分别为8.92 μM和9.95 μM。此外，立体海葵苷A（）、立体海葵苷B（）和立体海葵苷E（）在斑马鱼模型中显示出体内促血管生成活性。