Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, People's Republic of China.
J Nat Prod. 2024 Apr 26;87(4):1150-1158. doi: 10.1021/acs.jnatprod.4c00112. Epub 2024 Mar 28.
A detailed chemical study of the extract from the soft coral resulted in the isolation and identification of seven new sesquiterpenoids, bellissinanes A-G (-), along with four new diterpenes (-). Bellissinane A () is the third reported nardosinane-type sesquiterpene bearing a 6/5/6 tricyclic system. Bellissinanes C and D (, ) contain a phenylethylamine fragment, which is relatively unusual in marine organisms. Bellissinanes E-G (-) belong to the rare class of nornardosinane sesquiterpenoids. Structurally uncommon octahydro-1-indenyl-type and prenyleudesmane-type skeletons were characterized for herpetopanone B () and bellissimain A (), respectively. Bellissinane E () exhibited in vivo angiogenesis-promoting activity.
对软珊瑚提取物进行了详细的化学研究，从中分离并鉴定出了 7 种新的倍半萜类化合物，即贝利斯烷 A-G（-），以及 4 种新的二萜类化合物（-）。贝利斯烷 A（）是第三种报道的具有 6/5/6 三环系统的那沙定型倍半萜。贝利斯烷 C 和 D（，）含有一个苯乙胺片段，这在海洋生物中相对不常见。贝利斯烷 E-G（-）属于罕见的诺那沙定型倍半萜类。海鞘酮 B（）和贝利斯美烷 A（）分别具有结构不常见的八氢-1-茚基型和异戊烯基刘德烷型骨架。贝利斯烷 E（）表现出体内促进血管生成的活性。
