Mahendram Sujeivan, Christo Paul J
Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
J Pers Med. 2025 Mar 19;15(3):119. doi: 10.3390/jpm15030119.
Chronic low back pain has traditionally been thought to stem from intervertebral disc degeneration. However, emerging evidence over the last few decades has revealed other contributing sources. One such etiology of chronic non-radiating axial low back pain has been attributed to vertebral end plate disruption and degeneration, leading to basivertebral nerve-mediated nociception. These degenerative events, described as Modic changes on MRI, provide a means of diagnosis and offer personalized treatment options, like minimally invasive radiofrequency ablation, to help address this source of low back pain. This review focuses on recent advancements, rationale, efficacy, and safety profile intraosseous basivertebral nerve ablation in the treatment of vertebrogenic back pain, and discusses current knowledge gaps that may help guide future research in the field.
慢性下腰痛传统上被认为源于椎间盘退变。然而，过去几十年出现的证据揭示了其他致病因素。慢性非放射性轴向性下腰痛的一种病因被认为是椎体终板破坏和退变，导致椎基底神经介导的伤害感受。这些退变事件在磁共振成像（MRI）上被描述为Modic改变，提供了一种诊断方法，并提供了个性化的治疗选择，如微创射频消融，以帮助解决这种下腰痛的病因。本综述重点关注椎体内椎基底神经消融治疗脊椎源性背痛的最新进展、原理、疗效和安全性，并讨论当前的知识空白，这些空白可能有助于指导该领域未来的研究。
