经皮入骨椎体下脊神经射频消融术后与下腰痛相关的医疗保健利用:三项前瞻性临床试验的汇总分析。
Low back pain-related healthcare utilization following intraosseous basivertebral nerve radiofrequency ablation: a pooled analysis from three prospective clinical trials.
机构信息
Department of Physical Medicine and Rehabilitation, University of Utah School of Medicine, Salt Lake City, UT 84108, United States.
Health Economist, Technomics Research, LLC, Medina, MN 55356, United States.
出版信息
Pain Med. 2024 Jan 4;25(1):20-32. doi: 10.1093/pm/pnad114.
BACKGROUND
The effectiveness and safety of intraosseous basivertebral nerve ablation (BVNA) for treating vertebrogenic pain is established, but low back pain-related healthcare utilization (LBPr-HU) following BVNA continues to be defined.
METHODS
LBPr-HU data were pooled from 3 prospective studies. LBPr-HU categories of interest included non-invasive conservative care, opioid utilization, lumbosacral spinal injection (LSI), lumbosacral radiofrequency ablation (LRFA), and lumbosacral spinal surgery. Pre- and post-BVNA LBPr-HU were compared at both 1- and 5-years using McNemar's test for proportions and paired t-tests for means.
RESULTS
Two hundred forty-seven patients received BVNA and had 1-year follow-up; 205 had long-term follow-up (mean of 5.3 ± 1.33 years). Twenty-seven percent fewer participants initiated conservative care in the year post-BVNA compared to the year preceding BVNA (P < .001; 95% CI 19.8-34.5). Of 77/247 participants taking opioids at baseline, 40.3% and 61.7% fewer were taking them at one-year and 5.3 ± 1.33 years post-BVNA, respectively (P < .001). Of participants receiving LSIs in the year preceding BVNA, 81.2% fewer received LSI(s) in the year post-BVNA (P < .001; 95% CI 70.7-90.7); a 76.4% reduction in LSIs was maintained through a mean of 5.3 ± 1.33 years post-BVNA. LRFA rates were 1.6% at 1-year post-BVNA and 8.3% at 5.3 ± 1.33 years post-BVNA. Lumbar fusion surgery was 0.8% at 1-year post-BVNA and 6.5% at 5.3 ± 1.33 years post-BVNA.
CONCLUSIONS
In this aggregate analysis of patients with vertebrogenic pain, utilization of conservative care, opioids, LSIs, and LRFA were substantially reduced through 5 years post-BVNA compared to baseline. Lumbar fusion rates were less than half the published value at 5 years in similar populations.
背景
经证实,经骨椎弓根基底神经消融术(BVNA)治疗椎源性疼痛的有效性和安全性良好,但接受 BVNA 治疗后的与下腰痛相关的医疗保健利用(LBPr-HU)仍有待明确。
方法
从 3 项前瞻性研究中汇总 LBPr-HU 数据。LBPr-HU 主要关注的类别包括非侵入性保守治疗、阿片类药物的使用、腰骶部脊柱注射(LSI)、腰骶部射频消融术(LRFA)和腰骶部脊柱手术。采用 McNemar 检验比较比例和配对 t 检验比较均值,分别比较 1 年和 5 年时 BVNA 前后的 LBPr-HU。
结果
247 例患者接受了 BVNA 治疗,并进行了 1 年随访;205 例患者进行了长期随访(平均随访时间为 5.3±1.33 年)。与 BVNA 治疗前相比,BVNA 治疗后 1 年内开始保守治疗的患者减少了 27%(P<0.001;95%CI 19.8-34.5)。基线时接受阿片类药物治疗的 77/247 例患者中,1 年和 5.3±1.33 年后分别有 40.3%和 61.7%的患者停止服用阿片类药物(P<0.001)。在 BVNA 治疗前的 1 年中接受 LSI 的患者中,BVNA 治疗后 1 年内接受 LSI 的患者减少了 81.2%(P<0.001;95%CI 70.7-90.7);在 BVNA 治疗后 5.3±1.33 年内,LSI 减少了 76.4%。LRFA 的发生率在 1 年后为 1.6%,在 5.3±1.33 年后为 8.3%。1 年后腰椎融合手术的发生率为 0.8%,5.3±1.33 年后为 6.5%。
结论
在这项汇总分析中,与基线相比,接受 BVNA 治疗的椎源性疼痛患者在 5 年内保守治疗、阿片类药物、LSI 和 LRFA 的利用率显著降低。在类似人群中,5 年时的腰椎融合率不到已发表值的一半。