Zhang Bin, Zhao Meizi, Cong Xiangru, Liu Chunyu, Li Chaofei, Qiu Yu, Li Sha, Chen Yanying, Li Xiaoxue, Li Penghui
School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin 300384, China.
Tianjin Eco-Environmental Monitoring Center, Tianjin 300191, China.
Toxics. 2025 Mar 14;13(3):214. doi: 10.3390/toxics13030214.
Studies have shown that per- and polyfluoroalkyl substances (PFAS) may impact thyroid function in human health. While the consistency between PFAS exposure and thyroid health effects in pregnant women has been validated, the effects on men and non-pregnant women remains inconclusive. To address this, a meta-analysis was carried out in this paper, with 14 eligible studies retrieved from Embase, PubMed, and Web of Science that were published up to 2 June 2024, focusing on the relationship between PFAS exposure and its effect on thyroid hormone levels in the human body. The thyroid function indexes analyzed included thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), free T3 (FT3), and free T4 (FT4). The estimated value (β) and the corresponding confidence interval (95% CI) were extracted from the literature. A heterogeneity test was carried out, and the sensitivity analysis and publication bias of the studies were analyzed using Stata 18.0. The results revealed that in men and non-pregnant women, PFOA was positively correlated with FT3 (β = 0.011, 95% CI = 0.001, 0.02, I = 13.4). However, no significant associations were found between exposure to other PFAS and thyroid hormones. A subgroup analysis further indicated that the correlations between PFAS exposure and thyroid hormone levels were more significant in adolescents, in both America and Europe.
研究表明，全氟和多氟烷基物质（PFAS）可能会影响人体健康中的甲状腺功能。虽然已证实孕妇接触PFAS与甲状腺健康影响之间具有一致性，但对男性和非孕妇的影响仍无定论。为解决这一问题，本文进行了一项荟萃分析，从Embase、PubMed和Web of Science中检索了截至2024年6月2日发表的14项符合条件的研究，重点关注PFAS暴露与其对人体甲状腺激素水平影响之间的关系。分析的甲状腺功能指标包括促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）、游离T3（FT3）和游离T4（FT4）。从文献中提取估计值（β）和相应的置信区间（95%CI）。进行了异质性检验，并使用Stata 18.0分析了研究的敏感性分析和发表偏倚。结果显示，在男性和非孕妇中，全氟辛酸（PFOA）与FT3呈正相关（β = 0.011，95%CI = 0.001，0.02，I = 13.4）。然而，未发现接触其他PFAS与甲状腺激素之间存在显著关联。亚组分析进一步表明，在美国和欧洲的青少年中，PFAS暴露与甲状腺激素水平之间的相关性更为显著。
