Ahmadirad Hamid, Farhadnejad Hossein, Norouzzadeh Mostafa, Jahromi Mitra Kazemi, Mokhtari Ebrahim, Omrani Morteza, Teymoori Farshad, Sadeghi Reza, Mirmiran Parvin, Bagherian Maryam
Nutrition and Endocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Cancer Epidemiol. 2025 Jun;96:102807. doi: 10.1016/j.canep.2025.102807. Epub 2025 Mar 25.
Recently, observational studies have focused on dietary advanced glycation end products (dAGEs) as predictive risk factors for chronic diseases and their related mortality. The current systematic review and meta-analysis aimed to synthesize the available evidence and quantify the possible association of dAGEs and risk of all-cause or cause-specific mortality.
A comprehensive and systematic search was conducted in online literature databases, including PubMed, Scopus and Web of Science until January 2025 without any language limitation. The hazard ratio (HR) with 95 % confidence interval (CI) for the included studies were extracted and converted into log HR. Also, we used a random-effects model with inverse variance weighting method to compute the pooled effect size.
Six eligible studies (including 18 reports) were included in the current meta-analysis. 111,543 participants, aged 45.6-79 years old, participated in these observational studies, and the duration of follow-up varied from 3.8 to 16 years. According to the pooled results of our analysis, no significant association was observed between dAGEs and its components with the risk of all-cause mortality (HR=1.02; 95 %CI=0.92, 1.13; I= 73.2 %), cancer mortality (HR=1.00; 95 %CI=0.88, 1.13; I= 41.0 %) and CVDs mortality (HR=1.16; 95 %CI=0.86, 1.55; I=86.1 %). Sex, target population, dAGEs components, region, dAGEs assessment method, and dietary data collection methods were the sources of heterogeneity.
In conclusion, our study suggested that there was no significant association between dAGEs intake and all-cause or cause-specific mortality.
最近，观察性研究聚焦于膳食晚期糖基化终产物（dAGEs），将其作为慢性疾病及其相关死亡率的预测风险因素。当前的系统评价和荟萃分析旨在综合现有证据，并量化dAGEs与全因或特定原因死亡率风险之间的可能关联。
在包括PubMed、Scopus和Web of Science在内的在线文献数据库中进行了全面系统的检索，直至2025年1月，无任何语言限制。提取纳入研究的风险比（HR）及95%置信区间（CI），并转换为对数HR。此外，我们使用具有逆方差加权法的随机效应模型来计算合并效应量。
本荟萃分析纳入了六项符合条件的研究（包括18份报告）。111,543名年龄在45.6至79岁之间的参与者参与了这些观察性研究，随访时间从3.8年至16年不等。根据我们分析的合并结果，未观察到dAGEs及其成分与全因死亡率风险（HR = 1.02；95%CI = 0.92, 1.13；I = 73.2%）、癌症死亡率（HR = 1.00；95%CI = 0.88, 1.13；I = 41.0%）和心血管疾病死亡率（HR = 1.16；95%CI = 0.86, 1.55；I = 86.1%）之间存在显著关联。性别、目标人群、dAGEs成分、地区、dAGEs评估方法和膳食数据收集方法是异质性的来源。
总之，我们的研究表明，dAGEs摄入量与全因或特定原因死亡率之间无显著关联。
