Wu Haonan, Liu Ziyu, Li Yanan
Department of Respiratory, Children's Medical Center, The First Hospital of Jilin University, Changchun, China; Clinical Research Center for Child Health, The First Hospital of Jilin University, Changchun, China.
The First Hospital of Jilin University, Changchun, China.
Microb Pathog. 2025 Jun;203:107500. doi: 10.1016/j.micpath.2025.107500. Epub 2025 Mar 24.
In recent years, the role of the intestinal microbiota in regulating host health and immune balance has attracted widespread attention. This study provides an in-depth analysis of the close relationship between the intestinal microbiota and respiratory system diseases, with a focus on three common respiratory virus infections, including respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and influenza virus. The research indicates that during RSV infection, there is a significant decrease in intestinal microbial diversity, suggesting the impact of the virus on the intestinal ecosystem. In SARS-CoV-2 infection, there are evident alterations in the intestinal microbiota, which are positively correlated with the severity of the disease. Similarly, influenza virus infection is associated with dysbiosis of the intestinal microbiota, and studies have shown that the application of specific probiotics exhibits beneficial effects against influenza virus infection. Further research indicates that the intestinal microbiota exerts a wide and profound impact on the occurrence and development of respiratory system diseases through various mechanisms, including modulation of the immune system and production of short-chain fatty acids (SCFAs). This article comprehensively analyzes these research advances, providing new perspectives and potential strategies for the prevention and treatment of future respiratory system diseases. This study not only deepens our understanding of the relationship between the intestinal microbiota and respiratory system diseases but also offers valuable insights for further exploring the role of host-microbiota interactions in the development of diseases.
近年来，肠道微生物群在调节宿主健康和免疫平衡中的作用已引起广泛关注。本研究深入分析了肠道微生物群与呼吸系统疾病之间的密切关系，重点关注三种常见的呼吸道病毒感染，包括呼吸道合胞病毒（RSV）、严重急性呼吸综合征冠状病毒2（SARS-CoV-2）和流感病毒。研究表明，在RSV感染期间，肠道微生物多样性显著降低，这表明病毒对肠道生态系统有影响。在SARS-CoV-2感染中，肠道微生物群有明显改变，且与疾病严重程度呈正相关。同样，流感病毒感染与肠道微生物群失调有关，研究表明，应用特定益生菌对流感病毒感染具有有益作用。进一步研究表明，肠道微生物群通过多种机制对呼吸系统疾病的发生和发展产生广泛而深远的影响，包括调节免疫系统和产生短链脂肪酸（SCFAs）。本文全面分析了这些研究进展，为未来呼吸系统疾病的预防和治疗提供了新的视角和潜在策略。这项研究不仅加深了我们对肠道微生物群与呼吸系统疾病之间关系的理解，也为进一步探索宿主-微生物群相互作用在疾病发展中的作用提供了有价值的见解。
