Liang Mingxin, Dong Qinqin, Wu Weiyi, Fan Juan
School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, Sichuan, China.
Department of Pediatrics, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, 610072, Sichuan, China.
Clin Rev Allergy Immunol. 2025 Jan 28;68(1):8. doi: 10.1007/s12016-024-09018-x.
The intestinal microbiota is a complex community of organisms present in the human gastrointestinal tract, some of which can produce short-chain fatty acids (SCFAs) through the fermentation of dietary fiber. SCFAs play a major role in mediating the intestinal microbiota's regulation of host immunity and intestinal homeostasis. Respiratory syncytial virus (RSV) can cause an imbalance between anti-inflammatory and proinflammatory responses in the host. In addition, changes in SCFA levels and the structure of the intestinal microbiota have been observed after RSV infection. Therefore, there may be a link between SCFAs and RSV infection, and SCFAs are expected to be therapeutic targets for RSV infection.
肠道微生物群是存在于人类胃肠道中的一个复杂的生物群落，其中一些微生物可通过膳食纤维发酵产生短链脂肪酸（SCFA）。SCFA在介导肠道微生物群对宿主免疫和肠道稳态的调节中起主要作用。呼吸道合胞病毒（RSV）可导致宿主抗炎和促炎反应之间的失衡。此外，在RSV感染后观察到SCFA水平和肠道微生物群结构的变化。因此，SCFA与RSV感染之间可能存在联系，并且SCFA有望成为RSV感染的治疗靶点。
