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Emerging Pathways of Action of Eicosapentaenoic Acid (EPA).

作者信息

Bhatt Deepak L, Libby Peter, Mason R Preston

机构信息

Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

JACC Basic Transl Sci. 2025 Mar;10(3):396-400. doi: 10.1016/j.jacbts.2024.10.010.

DOI:10.1016/j.jacbts.2024.10.010
PMID:40139880
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12013833/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aebe/12013833/029dfcb785e5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aebe/12013833/d6fec218825c/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aebe/12013833/029dfcb785e5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aebe/12013833/d6fec218825c/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aebe/12013833/029dfcb785e5/gr1.jpg

相似文献

1
Emerging Pathways of Action of Eicosapentaenoic Acid (EPA).二十碳五烯酸（EPA）的新兴作用途径
JACC Basic Transl Sci. 2025 Mar;10(3):396-400. doi: 10.1016/j.jacbts.2024.10.010.
2
Eicosapentaenoic Acid for Cardiovascular Events Reduction- Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.二十碳五烯酸对心血管事件减少的作用——随机对照试验的系统评价和网络荟萃分析。
J Cardiol. 2022 Nov;80(5):416-422. doi: 10.1016/j.jjcc.2022.07.008. Epub 2022 Jul 29.
3
Dietary Eicosapentaenoic Acid Improves Ozone-Induced Pulmonary Inflammation in C57BL/6 Mice.膳食二十碳五烯酸可改善臭氧诱导的C57BL/6小鼠肺部炎症。
J Nutr. 2025 Feb;155(2):465-475. doi: 10.1016/j.tjnut.2024.11.006. Epub 2024 Nov 12.
4
Eicosapentaenoic Acid Versus Docosahexaenoic Acid as Options for Vascular Risk Prevention: A Fish Story.二十碳五烯酸与二十二碳六烯酸作为预防血管风险的选择：一个与鱼有关的故事
Am J Ther. 2016 May-Jun;23(3):e905-10. doi: 10.1097/MJT.0000000000000165.
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Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis.ω-3 脂肪酸对冠状动脉血运重建和心血管事件的影响：一项荟萃分析。
Eur J Prev Cardiol. 2024 Nov 11;31(15):1863-1875. doi: 10.1093/eurjpc/zwae184.
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Does the ratio of eicosapentaenoic acid to docosahexaenoic acid matter in cancer treatment? A systematic review of their effects on cachexia-related inflammation.二十碳五烯酸与二十二碳六烯酸的比例在癌症治疗中有影响吗？系统评价它们对恶病质相关炎症的影响。
Nutrition. 2024 Aug;124:112466. doi: 10.1016/j.nut.2024.112466. Epub 2024 Apr 7.
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Icosapent ethyl in cardiovascular prevention: Resolution of inflammation through the eicosapentaenoic acid - resolvin E1 - ChemR23 axis.二十碳五烯酸乙酯在心血管预防中的作用：通过二十碳五烯酸 - 分辨率素 E1 - ChemR23 轴解决炎症。
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Low unesterified:esterified eicosapentaenoic acid (EPA) plasma concentration ratio is associated with bipolar disorder episodes, and omega-3 plasma concentrations are altered by treatment.低游离型：酯化二十碳五烯酸（EPA）血浆浓度比值与双相情感障碍发作有关，且ω-3血浆浓度会因治疗而改变。
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Effects of long-chain omega-3 polyunsaturated fatty acids on reducing anxiety and/or depression in adults; A systematic review and meta-analysis of randomised controlled trials.长链ω-3 多不饱和脂肪酸对降低成年人焦虑和/或抑郁的影响：一项随机对照试验的系统评价和荟萃分析。
Prostaglandins Leukot Essent Fatty Acids. 2023 May;192:102572. doi: 10.1016/j.plefa.2023.102572. Epub 2023 Apr 2.

本文引用的文献

1
EPA Induces an Anti-Inflammatory Transcriptome in T Cells, Implicating a Triglyceride-Independent Pathway in Cardiovascular Risk Reduction.二十碳五烯酸（EPA）在T细胞中诱导抗炎转录组，提示存在一条不依赖甘油三酯的降低心血管风险途径。
JACC Basic Transl Sci. 2025 Mar;10(3):383-395. doi: 10.1016/j.jacbts.2024.09.002. Epub 2024 Oct 30.
2
Eicosapentaenoic Acid Improves Endothelial Nitric Oxide Bioavailability Via Changes in Protein Expression During Inflammation.二十碳五烯酸通过炎症过程中的蛋白表达变化改善内皮型一氧化氮生物利用度。
J Am Heart Assoc. 2024 Jul 16;13(14):e034076. doi: 10.1161/JAHA.123.034076. Epub 2024 Jul 3.
3
Randomized Trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy-Statin and Eicosapentaenoic Acid (RESPECT-EPA).
随机试验评估联合治疗-他汀类药物和二十碳五烯酸（RESPECT-EPA）在二级预防中的疗效。
Circulation. 2024 Aug 6;150(6):425-434. doi: 10.1161/CIRCULATIONAHA.123.065520. Epub 2024 Jun 14.
4
Benefit of icosapent ethyl on coronary physiology assessed by computed tomography angiography fractional flow reserve: EVAPORATE-FFRCT.依泽替米贝对 CT 血管成像血流储备分数评估的冠状动脉生理学的影响：EVAPORATE-FFRCT 研究。
Eur Heart J Cardiovasc Imaging. 2023 Jun 21;24(7):866-873. doi: 10.1093/ehjci/jead063.
5
Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials.炎症和胆固醇作为接受他汀类药物治疗患者心血管事件的预测因素：三项随机试验的联合分析
Lancet. 2023 Apr 15;401(10384):1293-1301. doi: 10.1016/S0140-6736(23)00215-5. Epub 2023 Mar 6.
6
Effect of omega-3 fatty acids on cardiovascular outcomes: A systematic review and meta-analysis.ω-3脂肪酸对心血管结局的影响：一项系统评价和荟萃分析。
EClinicalMedicine. 2021 Jul 8;38:100997. doi: 10.1016/j.eclinm.2021.100997. eCollection 2021 Aug.
7
Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid.ω-3 脂肪酸二十碳五烯酸的心血管保护作用的新机制。
Arterioscler Thromb Vasc Biol. 2020 May;40(5):1135-1147. doi: 10.1161/ATVBAHA.119.313286. Epub 2020 Mar 26.
8
Reduction in First and Total Ischemic Events With Icosapent Ethyl Across Baseline Triglyceride Tertiles.二十碳五烯酸乙酯在不同基线甘油三酯三分位数水平下对首次及总缺血事件的降低作用。
J Am Coll Cardiol. 2019 Aug 27;74(8):1159-1161. doi: 10.1016/j.jacc.2019.06.043.
9
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia.依泽替米贝降低严重高甘油三酯血症患者心血管风险
N Engl J Med. 2019 Jan 3;380(1):11-22. doi: 10.1056/NEJMoa1812792. Epub 2018 Nov 10.
10
Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis.二十碳五烯酸对高胆固醇血症患者主要冠脉事件的影响（日本 EPA 脂质干预研究）：一项随机开放标签、终点设盲的分析。
Lancet. 2007 Mar 31;369(9567):1090-8. doi: 10.1016/S0140-6736(07)60527-3.