Huang Shiyu, Huang Gangliang
Key Laboratory of Carbohydrate Science and Engineering, Chongqing Key Laboratory of Inorganic Functional Materials, Chongqing Normal University, Chongqing, 401331, China.
School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400700, China.
Discov Nano. 2025 Mar 26;20(1):56. doi: 10.1186/s11671-025-04239-1.
Berberine, also known as Xiaobojian (XBJ), is a quaternary ammonium alkaloid isolated from the traditional Chinese medicine Coptis chinensis, and is the main effective ingredient for antibacterial purpose. This work systematically reviewed recent researches on XBJ in the whole range of delivery technologies. Compared with XBJ monomer administration, other forms of drug administration, such as tablets, pellets, XBJ polymer delivery system, lipid delivery system, superdeformed vesicles nanocrystallization or emulsification of XBJ and some special substances, will increase the absorption of XBJ. XBJ can be administered through various carriers, including oral administration and topical application. The importance of XBJ carrier administration is mainly reflected in wide application prospects, various pharmacological effects, and improving drug efficacy.
黄连素，又称小檗碱（XBJ），是从传统中药黄连中分离出的一种季铵生物碱，是抗菌的主要有效成分。本研究系统回顾了近年来黄连素在各种给药技术方面的研究。与黄连素单体给药相比，其他给药形式，如片剂、微丸、黄连素聚合物给药系统、脂质给药系统、超变形囊泡、黄连素与某些特殊物质的纳米结晶或乳化，均会增加黄连素的吸收。黄连素可通过多种载体给药，包括口服和局部应用。黄连素载体给药的重要性主要体现在广泛的应用前景、多种药理作用以及提高药物疗效方面。
