Sun Guofang, Liang Jianjun, Chen Dechao, Zhao Kongjun, Liu Wangmi
Department of Orthopaedics, Shengzhou Chinese Medicine Hospital, Shaoxing, 312400, China.
Department of Orthopaedics, Daishan First People's Hospital, Zhoushan, 316200, China.
BMC Musculoskelet Disord. 2025 Mar 26;26(1):300. doi: 10.1186/s12891-025-08542-x.
The link between serum insulin level and low muscle mass among older adults is not yet fully understood. This study seeks to investigate this association using data from a nationally representative large-scale survey.
The study utilized data from two waves of the China Health and Nutrition Survey (CHNS) conducted in 2009 and 2015. Subjects meeting the inclusion criteria were classified according to the Asia Working Group for Sarcopenia 2019 criteria. The study employed ordinary least squares (OLS) regression models to analyze the cross-sectional association between appendicular skeletal muscle mass (ASM) and serum insulin level. Additionally, based on the median insulin level in the population without low muscle mass in 2009, these individuals were divided into high insulin and low insulin groups. Logistic regression models were utilized to examine the longitudinal association between low muscle mass and serum insulin level.
In 2009, a cross-sectional association study enrolled a total of 2329 participants aged over 60 years, with 53.1% women and a median age of 68.00 years. The prevalence of low muscle mass in the study population was 30.83%, with females accounting for 60.03%. In the adjusted OLS regression model based on blood biomarker, serum insulin level was positively associated with ASM (β = 0.075, 95% confidence interval (95% CI): 0.034-0.117, P < 0.01). A total of 944 individuals from the 2009 population without low muscle mass were divided into high insulin and low insulin groups based on the median insulin level, and were followed up until 2015. It was found that there was a significant difference in the incidence of low muscle mass between the two groups. (12.44% vs. 7.45%, P = 0.01). The adjusted logistic regression models indicated that higher serum insulin levels were associated with a reduced incidence of low muscle mass (Hazard ratio = 0.958, 95% CI: 0.925-0.989, P = 0.01).
Adequate serum insulin level could potentially serve as a protective factor in preserving healthy muscle mass among Chinese adults aged 60 and above.
Not applicable.
老年人血清胰岛素水平与低肌肉量之间的联系尚未完全明确。本研究旨在利用一项具有全国代表性的大规模调查数据来探究这种关联。
本研究使用了2009年和2015年进行的两轮中国健康与营养调查（CHNS）的数据。符合纳入标准的受试者根据2019年亚洲肌少症工作组标准进行分类。本研究采用普通最小二乘法（OLS）回归模型来分析四肢骨骼肌量（ASM）与血清胰岛素水平之间的横断面关联。此外，根据2009年非低肌肉量人群的胰岛素水平中位数，将这些个体分为高胰岛素组和低胰岛素组。采用逻辑回归模型来检验低肌肉量与血清胰岛素水平之间的纵向关联。
2009年，一项横断面关联研究共纳入2329名60岁以上参与者，其中女性占53.1%，中位年龄为68.00岁。研究人群中低肌肉量的患病率为30.83%，女性占60.03%。在基于血液生物标志物的校正OLS回归模型中，血清胰岛素水平与ASM呈正相关（β = 0.075，95%置信区间（95%CI）：0.034 - 0.117，P < 0.01）。根据胰岛素水平中位数，将2009年非低肌肉量人群中的944名个体分为高胰岛素组和低胰岛素组，并随访至2015年。发现两组之间低肌肉量的发生率存在显著差异（12.44%对7.45%，P = 0.01）。校正后的逻辑回归模型表明，较高的血清胰岛素水平与较低的低肌肉量发生率相关（风险比 = 0.958，95%CI：0.925 - 0.989，P = 0.01）。
充足的血清胰岛素水平可能是60岁及以上中国成年人维持健康肌肉量的一个保护因素。
不适用。
