Campagna Roberto, Schiavoni Valentina, Rao Loredana, Bambini Fabrizio, Frontini Andrea, Sampalmieri Francesco, Salvolini Eleonora, Memé Lucia
Department of Clinical Sciences, Polytechnic University of Marche, 60121 Ancona, Italy.
Department of Life and Environmental Sciences, Polytechnic University of Marche, 60121 Ancona, Italy.
Materials (Basel). 2025 Mar 11;18(6):1234. doi: 10.3390/ma18061234.
Nowadays, custom-made subperiosteal implants are emerging as a solution in all those cases where there is lack of healthy bone tissue to support endosseous implants. The development of innovative techniques has allowed the production of grids that precisely match the patient's anatomy. Elucidating the impact of laser-melted Ti6Al4V grids on both hard and soft tissues with which they come into contact is, therefore, mandatory. In this study, we analyzed the effects of five different surface treatments on a human osteoblast-like cell line (MG-63). In particular, the cell proliferation and osteogenic response were evaluated. Taken together, our data demonstrate that in our in vitro setting, the new surface treatment developed by Al Ti color could enhance osteogenesis and improve the stabilization of the implant to the residual bone by stimulating the best osteogenic response in MG-63 cells. Although further studies are required to validate our data in an in vivo model, our results provide the basis for future advances in implantology for the long-term maintenance of osseointegration.
如今，定制的骨膜下植入物正在成为所有缺乏健康骨组织来支撑骨内植入物的病例的一种解决方案。创新技术的发展使得能够生产出与患者解剖结构精确匹配的网格。因此，阐明激光熔化的Ti6Al4V网格对与其接触的硬组织和软组织的影响是必不可少的。在本研究中，我们分析了五种不同表面处理对人成骨样细胞系（MG-63）的影响。特别地，评估了细胞增殖和成骨反应。综合来看，我们的数据表明，在我们的体外实验中，Al Ti color开发的新表面处理可以通过刺激MG-63细胞中最佳的成骨反应来增强成骨作用，并改善植入物与残余骨的稳定性。尽管需要进一步的研究在体内模型中验证我们的数据，但我们的结果为种植学在长期维持骨整合方面的未来进展提供了基础。
