利拉鲁肽治疗可恢复异丙肾上腺素诱导的心肌损伤后大鼠的心功能并预防心力衰竭。

Liraglutide Treatment Restores Cardiac Function After Isoprenaline-Induced Myocardial Injury and Prevents Heart Failure in Rats.

作者信息

Bajic Zorislava, Sobot Tanja, Smitran Aleksandra, Uletilovic Snezana, Mandić-Kovačević Nebojša, Cvjetkovic Tanja, Malicevic Ugljesa, Stanetic Bojan, Đukanović Đorđe, Maticic Milka, Jovicic Sanja, Djuric Dragan M, Stojiljkovic Milos P, Skrbic Ranko

机构信息

Department of Physiology, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, The Republic of Srpska, Bosnia and Herzegovina.

Centre for Biomedical Research, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, The Republic of Srpska, Bosnia and Herzegovina.

出版信息

Life (Basel). 2025 Mar 12;15(3):443. doi: 10.3390/life15030443.

DOI:10.3390/life15030443

PMID:40141787

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11943469/

Abstract

BACKGROUND

Myocardial injury (MI) is characterized by an increased level of at least one cardiac troponin. Experimental MI can be induced by isoprenaline, a β-adrenergic agonist, and it can lead to heart failure (HF). Liraglutide is glucagon-like 1 peptide receptor agonist used in diabetes management, but it has anti-inflammatory and antioxidative effects, which can be beneficial in treatment of HF. The aim of this study was to investigate the effects of liraglutide on isoprenaline-induced MI and prevention of HF.

METHODS

Male Wistar albino rats were divided into four groups: Con-received saline the first 2 days + saline the next 7 days; Iso-isoprenaline the first 2 days + saline the next 7 days; Lir-saline the first 2 days + liraglutide the next 7 days; Iso + Lir-isoprenaline the first 2 days + liraglutide the next 7 days. On day 10, blood samples were taken for biochemical analysis and oxidative stress marker evaluation, and hearts were isolated for pathohistological analysis. Cardiac function was assessed by electrocardiography (ECG) and echocardiography (ECHO).

RESULTS

Liraglutide treatment significantly attenuated oxidative stress, repaired ECG and ECHO parameters, and mitigated myocardial morphological changes induced by isoprenaline.

CONCLUSIONS

Liraglutide restores cardiac function in isoprenaline-induced HF.

摘要

背景

心肌损伤（MI）的特征是至少一种心肌肌钙蛋白水平升高。实验性MI可由β-肾上腺素能激动剂异丙肾上腺素诱导，并可导致心力衰竭（HF）。利拉鲁肽是一种用于糖尿病管理的胰高血糖素样肽1受体激动剂，但它具有抗炎和抗氧化作用，可能对HF治疗有益。本研究的目的是探讨利拉鲁肽对异丙肾上腺素诱导的MI的影响以及对HF的预防作用。

方法

将雄性Wistar白化大鼠分为四组：对照组——前2天给予生理盐水+后7天给予生理盐水；异丙肾上腺素组——前2天给予异丙肾上腺素+后7天给予生理盐水；利拉鲁肽组——前2天给予生理盐水+后7天给予利拉鲁肽；异丙肾上腺素+利拉鲁肽组——前2天给予异丙肾上腺素+后7天给予利拉鲁肽。在第10天，采集血样进行生化分析和氧化应激标志物评估，并分离心脏进行病理组织学分析。通过心电图（ECG）和超声心动图（ECHO）评估心脏功能。