Klamminger Gilbert Georg, Eltze Elke, Bitterlich Annick, Degirmenci Yaman, Hasenburg Annette, Wagner Mathias, Nigdelis Meletios P
Department of Obstetrics and Gynecology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Department of General and Special Pathology, Saarland University (USAAR), Saarland University Medical Center (UKS), 66421 Homburg, Germany.
J Clin Med. 2025 Mar 17;14(6):2045. doi: 10.3390/jcm14062045.
: To evaluate the prognostic impact of immunohistochemical ki-67 staining analysis regarding lymph node involvement and survival data (overall/progression-free survival) in squamous cell carcinoma of the vulva. : A systematic literature search of English and German articles was conducted (PubMed, Embase, Scopus, Web of Science) from 1980 to December 2023, including the search terms "vulvar Neoplasms", "vulvar cancer", "vulvar carcinoma", "vulvar tumor", "vulvar tumour", "vulvar malignancy", "vulvar malignant", "ki-67", "MIB-1", "MIB1", "proliferative index", "proliferative activity", "mitotic index", and "mitotic count". Study quality was assessed using a two-step "mixed-criteria" approach; to synthesize study results, a narrative summary is provided. : In total, 13 studies were included in this systematic literature review. In general, two distinct methods of staining interpretation could be retrieved: A "pattern-based" method, as well as a cell count-based method. Ten of the included studies examined the relationship between ki-67 and lymph node involvement, nine studies included survival data as a parameter of interest; and only five studies defined both groin lymph node metastasis and survival data as outcome variables. While nine out of ten studies found no statistically significant association between ki-67 staining and lymph node metastasis, five out of nine studies determined an association between ki-67 status and overall survival, especially when employing a "pattern-based" method of staining interpretation. : The prognostic value of ki-67 staining in terms of survival data has been reported ambivalently and should be subject to future studies. Furthermore, we did not find convincing evidence of an association between ki-67 and lymph node involvement.
评估免疫组化Ki-67染色分析对外阴鳞状细胞癌淋巴结受累及生存数据（总生存期/无进展生存期）的预后影响。：对1980年至2023年12月的英文和德文文章进行了系统的文献检索（PubMed、Embase、Scopus、Web of Science），检索词包括“外阴肿瘤”“外阴癌”“外阴 carcinoma”“外阴肿瘤”“外阴瘤”“外阴恶性肿瘤”“外阴恶性的”“Ki-67”“MIB-1”“MIB1”“增殖指数”“增殖活性”“有丝分裂指数”和“有丝分裂计数”。采用两步“混合标准”方法评估研究质量；为综合研究结果，提供了叙述性总结。：本系统文献综述共纳入13项研究。一般来说，可以检索到两种不同的染色解读方法：一种是“基于模式”的方法，以及一种基于细胞计数的方法。纳入的10项研究探讨了Ki-67与淋巴结受累之间的关系，9项研究将生存数据作为感兴趣的参数；只有5项研究将腹股沟淋巴结转移和生存数据均定义为结局变量。虽然10项研究中有9项未发现Ki-67染色与淋巴结转移之间存在统计学显著关联，但9项研究中有5项确定了Ki-67状态与总生存期之间的关联，尤其是采用“基于模式”的染色解读方法时。：关于生存数据，Ki-67染色的预后价值报道不一，应接受未来的研究。此外，我们未找到令人信服的证据证明Ki-67与淋巴结受累之间存在关联。
