Department of Ophthalmology the Fourth Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, China.
Indian J Ophthalmol. 2022 Dec;70(12):4319-4324. doi: 10.4103/ijo.IJO_1652_22.
To investigate the clinical effect of sodium hyaluronate eye drops combined with tobramycin, dexamethasone, and pranoprofen eye drops in the treatment of dry eye after phacoemulsification.
Medical records of 188 patients with dry eye after phacoemulsification, treated in our hospital from August 2020 to August 2021, were included and divided into groups based on the type of dry eye treatment. Patients in the control group (n = 90) were treated with tobramycin, dexamethasone, and pranoprofen eye drops. Patients in the test group (n = 98) were treated with sodium hyaluronate, tobramycin, dexamethasone, and pranoprofen eye drops. The tear secretion test (TST), film rupture time (BUT), corneal fluorescence staining (FS) score, levels of interleukin (IL)-6, and tumor necrosis factor (TNF)-α before the treatment and at 1 month follow-up, the overall total effective rate and the number of completely cured cases were compared between the two groups. Multiple linear regression was used to calculate coefficients for predicting clinical variables. Ordinal logistic regression was used to compute coefficients and odds ratios for predicting effective scores.
The total effective rate in the observation group (99%) was significantly higher than that in the control group (80.00%). After the treatment, the TST and BUT indexes of the observation group were higher compared to the control group, and the FS score of the observation group was lower than that of the control group. TNF-α and IL-6 levels of the observation group were lower compared to the control group. Logistic regression analysis demonstrated that the differences in the effective rate and clinical variables between the two groups remained significant after adjusting for the effect of age.
A combination of sodium hyaluronate, tobramycin, dexamethasone, and pranoprofen eye drops for the treatment of dry eye after phacoemulsification can improve the curative effect, reduce corneal fluorescein staining and inflammatory factor index levels compared to the treatment regimen lacking sodium hyaluronate eye drops.
探讨玻璃酸钠滴眼液联合妥布霉素、地塞米松、普拉洛芬滴眼液治疗白内障超声乳化术后干眼症的临床效果。
选取 2020 年 8 月至 2021 年 8 月在我院治疗的 188 例白内障超声乳化术后干眼症患者，根据干眼症治疗方式分组，对照组（n=90）采用妥布霉素、地塞米松、普拉洛芬滴眼液治疗，观察组（n=98）采用玻璃酸钠、妥布霉素、地塞米松、普拉洛芬滴眼液治疗。比较两组患者治疗前后的泪液分泌试验（TST）、泪膜破裂时间（BUT）、角膜荧光素染色（FS）评分、白细胞介素（IL）-6、肿瘤坏死因子（TNF）-α 水平，比较两组患者的总有效率和完全治愈例数。采用多元线性回归计算临床变量的预测系数，采用有序逻辑回归计算预测有效评分的系数和比值比。
观察组总有效率（99%）显著高于对照组（80.00%）。治疗后，观察组 TST、BUT 指标均高于对照组，FS 评分低于对照组；观察组 TNF-α、IL-6 水平低于对照组。经年龄校正后，两组患者的有效率和临床变量差异仍有统计学意义。
玻璃酸钠联合妥布霉素、地塞米松、普拉洛芬滴眼液治疗白内障超声乳化术后干眼症，可提高疗效，降低角膜荧光素染色和炎症因子指标水平，优于不含玻璃酸钠滴眼液的治疗方案。
