Jiménez Adriana, López-Ornelas Adolfo, Gutiérrez-de la Cruz Neptali, Puente-Rivera Jonathan, Mayen-Quinto Rodolfo David, Sánchez-Monciváis Anahí, Ignacio-Mejía Iván, Albores-Méndez Exsal M, Vargas-Hernández Marco Antonio, Estudillo Enrique
División de Investigación, Hospital Juárez de México, Mexico City 07760, Mexico.
Hospital Nacional Homeopático, Hospitales Federales de Referencia, Mexico City 06800, Mexico.
Int J Mol Sci. 2025 Mar 27;26(7):3057. doi: 10.3390/ijms26073057.
Tumor innervation is a complex interaction between nerves and cancer cells that consists of axons invading tumors, and its complexity remains largely unknown in humans. Although some retrospective studies have provided important insights into the relationship between nerves and tumors, further knowledge is required about this biological process. Animal experiments have elucidated several molecular and cellular mechanisms of tumor innervation; however, no experimental models currently exist to study interactions between human cancer and nerve cells. Human pluripotent stem cells can differentiate into neurons for research purposes; however, the use of these neurons to study interactions with cancer cells remains largely unexplored. Hence, here we analyze the potential of human pluripotent stem cells to study the interaction of cancer cells and neurons derived from human pluripotent stem cells to unravel the poorly understood mechanisms of human tumor innervation.
肿瘤神经支配是神经与癌细胞之间的复杂相互作用，包括轴突侵入肿瘤，而其复杂性在人类中仍 largely unknown。虽然一些回顾性研究对神经与肿瘤之间的关系提供了重要见解，但仍需要关于这一生物学过程的更多知识。动物实验已经阐明了肿瘤神经支配的几种分子和细胞机制；然而，目前尚无用于研究人类癌症与神经细胞之间相互作用的实验模型。人类多能干细胞可分化为神经元用于研究目的；然而，利用这些神经元研究与癌细胞的相互作用在很大程度上仍未得到探索。因此，我们在此分析人类多能干细胞在研究癌细胞与源自人类多能干细胞的神经元之间相互作用方面的潜力，以揭示人类肿瘤神经支配中尚未完全理解的机制。
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