Kochar A S
Am J Med. 1985 Jul;79(1):119-21. doi: 10.1016/0002-9343(85)90555-8.
Malignant melanoma developed in an apparently benign nevus four months after therapy with levodopa in a patient with Parkinson's disease. This case is reported, and previous reports of this possible causal relationship are reviewed. Although this and previously reported cases are not inconsistent with the unpredictable and variable natural history of malignant melanoma, it seems prudent to clinically monitor pigmentary lesions in patients receiving levodopa therapy. Biopsy specimens of suspicious lesions in these patients should be examined histologically, and if malignancy is found, alternate therapies for treatment of parkinsonism should be considered.
一名帕金森病患者在接受左旋多巴治疗四个月后，在一个看似良性的痣上发生了恶性黑色素瘤。本文报告了该病例，并回顾了此前关于这种可能因果关系的报告。尽管该病例及此前报告的病例与恶性黑色素瘤不可预测且多变的自然病程并不矛盾，但对接受左旋多巴治疗的患者的色素沉着病变进行临床监测似乎是谨慎之举。这些患者可疑病变的活检标本应进行组织学检查，如发现恶性病变，应考虑帕金森病的替代治疗方法。
