Abdelhafiz Ibrahim, Kessel Tobias, Vilcinskas Andreas, Lee Kwang-Zin
Fraunhofer Institute for Molecular Biology and Applied Ecology, Branch of Bioresources, Ohlebergsweg 12, D-35392 Giessen, Germany.
Institute for Insect Biotechnology, Justus Liebig University of Giessen, Heinrich-Buff-Ring 26-32, D-35392 Giessen, Germany.
Viruses. 2025 Mar 13;17(3):408. doi: 10.3390/v17030408.
, commonly known as spotted-wing drosophila, has emerged as a highly destructive pest in global fruit and wine production. The effectiveness of chemical control is significantly compromised by rapid resistance development and a limited range of insecticide options. Biological control presents a promising sustainable alternative. Our previous work suggested the La Jolla Virus (LJV) as a suitable candidate for the development of an insect virus-based control option. Here, we characterized the natural transmission and pathology of the virus. We tested various modes of horizontal transmission, including airborne, venereal and oral, and fecal routes. To understand LJV pathology in infected flies, we studied feeding behavior and demonstrated changes in food absorption compared to non-infected flies. We also investigated the impact on fecundity and egg-to-adult success rate. Altogether, these results collectively improve our understanding of LJV transmission in natural populations and the implication of infected flies in food ingestion and overall fitness.
，通常被称为斑翅果蝇，已成为全球水果和葡萄酒生产中极具破坏性的害虫。化学防治的有效性因抗性快速发展和杀虫剂选择范围有限而大打折扣。生物防治是一种有前景的可持续替代方法。我们之前的工作表明拉霍亚病毒（LJV）是开发基于昆虫病毒的防治方法的合适候选者。在此，我们对该病毒的自然传播和病理学进行了表征。我们测试了各种水平传播方式，包括空气传播、性传播、口服和粪便传播途径。为了解LJV在受感染果蝇中的病理学，我们研究了取食行为，并证明与未感染果蝇相比食物吸收发生了变化。我们还研究了对繁殖力和卵到成虫成功率的影响。总之，这些结果共同增进了我们对LJV在自然种群中的传播以及受感染果蝇在食物摄取和整体适应性方面的影响的理解。
