Shahoon Hossein, Dehghani Soltani Anahita, Dehghani Soltani Hormoz, Salmani Zahra, Sabzevari Berahman, Sajedi Seyed Masoud
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Shahed University, Tehran, Iran.
Department of Orthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3Periodontist, Private Practice, Tehran, Iran.
Eur Endod J. 2025 Mar;10(2):83-93. doi: 10.14744/eej.2024.30922.
Blood clot, platelet-rich fibrin, and plasma-rich plasma are the three most commonly used scaffolds in regenerative endodontic therapy. The current study aimed to evaluate the clinical outcomes of plasma-rich plasma (PRP) and platelet-rich fibrin (PRF) scaffolds and blood clot (BC) in regenerative endodontic therapy. For this systematic review and meta-analysis, international databases such as MEDLINE (PubMed and Ovid), Web of Science, and Scopus were searched between January 2013 and November 2023 using keywords relevant to the study objectives. Randomized controlled trials published in English that investigated the effects of BC, PRF, and PRP interventions compared to each other on permanent teeth with a six-month follow-up period were included in the study. The risk of bias was assessed using the Cochrane tool for randomized trials. Data were analyzed using STATA/MP software, employing odds ratios with fixed and random effects models in the meta-analysis. Fourteen randomized clinical trials involving 430 participants were reviewed. The present study did not reveal any statistically significant differences between BC and PRP regarding apical radiolucency healing (OR: -1.30, 95% CI; -2.68, 0.08; p=0.07, I2=0%, p=0.91) and apical closure (OR: -0.29, 95% CI; -1.07, 0.49; p=0.47, I2=32.63%, p=0.20). However, root-length increase in BC was greater compared to PRP (OR: 3.18, 95% CI; 2.78, 3.57; p<0.01) and PRF (OR: 1.75, 95% CI; 1.38, 2.13; p<0.01). The risk of bias was low for all studies, based on the Cochrane tool. BC is the preferred primary scaffold in regenerative endodontic therapy, while PRP and PRF are recommended for cases of severe canal bleeding. (EEJ-2024-05-079).
血凝块、富血小板纤维蛋白和富血浆血浆是再生牙髓治疗中最常用的三种支架。本研究旨在评估富血浆血浆（PRP）、富血小板纤维蛋白（PRF）支架和血凝块（BC）在再生牙髓治疗中的临床效果。对于这项系统评价和荟萃分析，在2013年1月至2023年11月期间，使用与研究目标相关的关键词对MEDLINE（PubMed和Ovid）、科学网和Scopus等国际数据库进行了检索。纳入研究的是发表于英文的随机对照试验，这些试验研究了BC、PRF和PRP干预措施在六个月随访期内对恒牙相互比较的效果。使用Cochrane随机试验工具评估偏倚风险。使用STATA/MP软件进行数据分析，在荟萃分析中采用固定效应模型和随机效应模型的比值比。对涉及430名参与者的14项随机临床试验进行了综述。本研究未发现BC和PRP在根尖透影区愈合方面存在任何统计学显著差异（比值比：-1.30，95%置信区间；-2.68，0.08；p = 0.07，I² = 0%，p = 0.91）以及根尖闭合方面存在差异（比值比：-0.29，95%置信区间；-1.07，0.49；p = 0.47，I² = 32.63%，p = 0.20）。然而，与PRP（比值比：3.18，95%置信区间；2.78，3.
