Adams Christopher, Fulton Greg
Department of Neurology, The University of Tennessee Health Science Center, Memphis, TN, USA.
Music Department, Seattle Pacific University, Seattle, WA, USA.
Neurosci Insights. 2025 Mar 24;20:26331055251329878. doi: 10.1177/26331055251329878. eCollection 2025.
A previous randomized pre-post cross-over study with 26 participants found positive changes in motor and non-motor symptoms in people with Parkinson's disease (PwPD) after six weeks of group classical guitar sessions but not customary and usual treatment.
To determine if a six-week group classical guitar instruction program improved motor function, mood, and quality of life for PwPD in comparison to a six-week group exercise program in a non-randomized cross-over pilot study.
Eighteen PwPD were enrolled and 15 completed the study. Group 1 (N = 10) received a six-week group guitar instruction program, and then a six-week group exercise program. Group 2 (N = 8) received a six-week group exercise program, and then a six-week guitar instruction program. Assessments were at baseline, six weeks, and 12 weeks. The groups were combined for analysis by two-tailed paired -tests due to the low sample size. Assessments included the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) motor sub-section, Hoehn and Yahr scale, Parkinson's Disease Questionnaire-39 (PDQ-39), Apathy Evaluation Scale-Self (AES-S), and Beck Depression Inventory II (BDI-II).
MDS-UPDRS mean motor scores decreased compared to pre-test scores with group guitar instruction (-5.3 points, < .001), but not group exercise (-0.47 points, = .85). BDI-II mean scores decreased by 2.13 ( = .08) and 1.87 points ( = .02) with group guitar instruction and group exercise, respectively. PDQ-39 mean scores decreased by 1.93 ( = .02) and 2.52 ( = .02) points with group guitar instruction and group exercise, respectively. AES-S mean scores decreased with group exercise (-2.40 points, = .03) but not group guitar instruction (-2.4 points, = .26).
Group guitar instruction could potentially help with both motor and non-motor symptoms in PwPD. There appears to be a specific effect of group guitar instruction on MDS-UPDRS motor scores that is not due to regular meetings and general exercises. This unfunded study was registered at ClinicalTrials.gov (NCT05917704).
一项先前针对26名参与者的随机前后交叉研究发现，帕金森病患者（PwPD）在参加为期六周的集体古典吉他课程后，其运动和非运动症状出现了积极变化，但在接受常规和惯常治疗后未出现此类变化。
在一项非随机交叉试点研究中，确定与为期六周的集体锻炼计划相比，为期六周的集体古典吉他教学计划是否能改善PwPD的运动功能、情绪和生活质量。
招募了18名PwPD，其中15名完成了研究。第1组（N = 10）接受为期六周的集体吉他教学计划，然后接受为期六周的集体锻炼计划。第2组（N = 8）接受为期六周的集体锻炼计划，然后接受为期六周的吉他教学计划。评估在基线、六周和十二周时进行。由于样本量较小，两组合并进行双尾配对检验分析。评估包括运动障碍协会统一帕金森病评定量表（MDS-UPDRS）运动部分、霍恩和雅尔量表、帕金森病问卷-39（PDQ-39）、自我冷漠评估量表（AES-S）和贝克抑郁量表第二版（BDI-II）。
与吉他教学组的测试前分数相比，MDS-UPDRS平均运动分数有所下降（-5.3分，<0.001），但锻炼组未下降（-0.47分，P = 0.85）。BDI-II平均分数在吉他教学组和锻炼组分别下降了2.13分（P = 0.08）和1.87分（P = 0.02）。PDQ-39平均分数在吉他教学组和锻炼组分别下降了1.93分（P = 0.02）和2.52分（P = 0.02）。AES-S平均分数在锻炼组下降了（-2.40分，P = 0.03），但在吉他教学组未下降（-2.4分，P = 0.26）。
集体吉他教学可能有助于改善PwPD的运动和非运动症状。集体吉他教学对MDS-UPDRS运动分数似乎有特定影响，这并非由于定期聚会和常规锻炼所致。这项自筹资金的研究已在ClinicalTrials.gov上注册（NCT05917704）。
