Elahi Muhammad Waqar, Huang Eric, Kumar Vikash, Ghias Mona, Shi David
Medicine, West Virginia University School of Medicine, Morgantown, USA.
Internal Medicine, West Virginia University School of Medicine, Morgantown, USA.
Cureus. 2025 Feb 24;17(2):e79550. doi: 10.7759/cureus.79550. eCollection 2025 Feb.
Fungal endocarditis (FE) is an uncommon and life-threatening disease with unacceptably high mortality rates. Only a handful of cases of FE caused by have been reported in the literature so far. We present a case of prosthetic valve endocarditis (PVE) in a 59-year-old woman with a history of prosthetic aortic valve who was admitted after outpatient blood cultures came positive for yeast (later identified as ). A trans-esophageal echocardiogram showed vegetation on the prosthetic aortic valve. The patient was successfully treated with intravenous (IV) micafungin as she was deemed unfit for valve replacement surgery due to multiple high-risk comorbidities. The patient was treated with six weeks of IV micafungin followed by oral fluconazole for lifelong suppression, and she remained well at follow-up six months later. In this report, we review the latest literature on FE and discuss the role of antifungal therapy in its management.
真菌性心内膜炎（FE）是一种罕见且危及生命的疾病，死亡率高得令人难以接受。迄今为止，文献中仅报道了少数几例由[具体真菌名称未给出]引起的FE病例。我们报告一例59岁有人工主动脉瓣病史的女性人工瓣膜心内膜炎（PVE）病例，该患者因门诊血培养酵母阳性（后鉴定为[具体真菌名称未给出]）而入院。经食管超声心动图显示人工主动脉瓣上有赘生物。由于多种高危合并症，该患者被认为不适合进行瓣膜置换手术，遂成功接受了静脉注射米卡芬净治疗。患者接受了六周的静脉注射米卡芬净治疗，随后口服氟康唑进行终身抑制治疗，六个月后的随访显示她情况良好。在本报告中，我们回顾了关于FE的最新文献，并讨论了抗真菌治疗在其管理中的作用。
