Chandramohan Divya, Aguilar Samantha, Gawrys Gerard, Wiederhold Nathan P, Traugott Kristi, Patterson Thomas F
Division of Infectious Diseases, Department of Medicine, University of Texas Health, San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States.
Department of Pharmacotherapy and Pharmacy Services, University of Texas Health, San Antonio, 4502 Medical Drive, San Antonio, TX 78229, United States.
IDCases. 2025 Apr 20;40:e02233. doi: 10.1016/j.idcr.2025.e02233. eCollection 2025.
Antifungal resistance in can develop to different classes of drugs, including the azoles and echinocandins. This organism is known to cause infective endocarditis with a particular predilection for prosthetic valves. Herein we present a case of recurrent fungemia with in a middle-aged woman with Tetralogy of Fallot who had a right ventricle to pulmonary artery conduit, and a transcatheter pulmonary valve replacement in the past. Her isolate showed increasing minimum inhibitory concentrations (MIC) to various antifungals with higher MICs to azoles, including resistance to fluconazole, resulting in limited treatment options. She had affliction of her prosthetic pulmonic valve with and was treated with the second-generation echinocandin, rezafungin, for six months. This case illustrates the tolerability profile of long-term treatment with rezafungin.
[具体菌种名称]的耐药性可能发展至对不同种类药物产生抗性，包括唑类和棘白菌素类。已知该菌可引起感染性心内膜炎，对人工瓣膜有特别的偏好。在此，我们报告一例患有法洛四联症的中年女性复发性真菌血症病例，该患者曾行右心室至肺动脉导管术，并于过去进行过经导管肺动脉瓣置换术。她的分离菌株对多种抗真菌药物的最低抑菌浓度（MIC）不断增加，对唑类药物的MIC更高，包括对氟康唑耐药，导致治疗选择有限。她的人工肺动脉瓣受到[具体菌种名称]感染，接受了第二代棘白菌素类药物瑞扎芬净治疗六个月。本病例说明了瑞扎芬净长期治疗的耐受性情况。
