Department of Proliferative Diseases, Nicolaus Copernicus Multidisciplinary Centre for Oncology and Traumatology, ul. Pabianicka 62, 93-513, Łódź, Poland.
Department of Bone Marrow Transplantation and Hematology-Oncology, Pathology, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland.
Sci Rep. 2021 Feb 22;11(1):4337. doi: 10.1038/s41598-021-83502-8.
Non-melanoma skin cancers (NMSCs) are the most common malignancies diagnosed in Caucasian populations. Basal cell carcinoma (BCC) is the most frequent skin cancer, followed by squamous cell carcinoma (SCC). Unfortunately, most European cancer registries do not record individual types of NMSC. To evaluate the incidence of primary BCCs and SCCs regarding age, sex, tumour site and tumour subtype to determine trends in epidemiology of both cancers. Retrospective analysis of BCCs and SCCs diagnosed and treated across seven sites in Poland from 1999 to 2019. We recorded 13,913 NMSCs occurring in 10,083 patients. BCC represented 85.2% of all cases. SCC patients were older than BCC patients (77.1 ± 11.3 years vs. 70.1 ± 12.3 years, p < 0.01). The nodular subtype was the most common subtype of BCC, followed by the superficial and infiltrative subtypes. The superficial BCC subtype was more common on photoprotected areas (p < 0.01), whereas the nodular BCC subtype occurred on the face (p < 0.01). The high-risk SCC subtypes were more common on face compared to low-risk SCC subtypes (p < 0.01). BCC and SCC are common malignancies developing at various ages and anatomical sites. These data underline the need for better registration policies regarding NMSC in order to improve prevention and treatment strategies for these tumours.
非黑色素瘤皮肤癌（NMSC）是白种人群中最常见的恶性肿瘤。基底细胞癌（BCC）是最常见的皮肤癌，其次是鳞状细胞癌（SCC）。不幸的是，大多数欧洲癌症登记处并不记录 NMSC 的具体类型。为了评估原发性 BCC 和 SCC 的发病率，按年龄、性别、肿瘤部位和肿瘤亚型进行评估，以确定这两种癌症的流行病学趋势。回顾性分析了波兰 7 个地区 1999 年至 2019 年期间诊断和治疗的 BCC 和 SCC。我们记录了 13913 例 NMSC，涉及 10083 名患者。BCC 占所有病例的 85.2%。SCC 患者比 BCC 患者年龄大（77.1±11.3 岁 vs. 70.1±12.3 岁，p<0.01）。结节型是 BCC 最常见的亚型，其次是浅表型和浸润型。浅表型 BCC 更常见于光保护部位（p<0.01），而结节型 BCC 则发生在面部（p<0.01）。高危 SCC 亚型比低危 SCC 亚型更常见于面部（p<0.01）。BCC 和 SCC 是常见的恶性肿瘤，发生在不同的年龄和解剖部位。这些数据强调了需要更好的 NMSC 登记政策，以改善这些肿瘤的预防和治疗策略。
