Eiger S M, Kluger M J
Am J Physiol. 1985 Jul;249(1 Pt 2):F69-73. doi: 10.1152/ajprenal.1985.249.1.F69.
Knochel and Seldin proposed that the lowered body temperature observed during uremia was caused by an elevation in the circulating levels of cyanate. To test this hypothesis, normal rabbits were infused with varying concentrations of sodium cyanate. Infusion of pharmacological doses of cyanate (plasma concentration rose to 1,080 +/- 70 microM, n = 5) resulted in reductions in body temperature similar to that found during uremia; however, when normal rabbits were nephrectomized the plasma cyanate concentration only rose from 3.7 +/- 1.6 to 18 +/- 1.8 microM (n = 8) by 1-day postnephrectomy (body temperature fell 0.33 +/- 0.1 degrees C, n = 6). Plasma cyanate concentration did not rise further on days 2 and 3 postnephrectomy, despite a continued fall in body temperature. Infusion of cyanate in control rabbits to plasma concentrations attained 1-3 days postnephrectomy did not result in a fall in body temperature. Based on the failure of pathophysiological concentrations of cyanate to cause a reduction in the body temperature of normal rabbits, we conclude that cyanate is not responsible for the lowered body temperature associated with the acute response to uremia.
克诺赫尔和塞尔丁提出，尿毒症期间观察到的体温降低是由循环中氰酸盐水平升高所致。为验证这一假说，给正常兔子输注不同浓度的氰酸钠。输注药理剂量的氰酸盐（血浆浓度升至1080±70微摩尔，n = 5）导致体温降低，与尿毒症期间观察到的情况相似；然而，正常兔子肾切除术后，到术后1天时血浆氰酸盐浓度仅从3.7±1.6升至18±1.8微摩尔（n = 8）（体温下降0.33±0.1摄氏度，n = 6）。肾切除术后第2天和第3天，尽管体温持续下降，但血浆氰酸盐浓度并未进一步升高。给对照兔子输注氰酸盐，使其血浆浓度达到肾切除术后1 - 3天的水平，并未导致体温下降。基于生理病理浓度的氰酸盐未能使正常兔子体温降低，我们得出结论，氰酸盐并非尿毒症急性反应相关体温降低的原因。
