Sand Trond, Uglem Martin, Johnsen Gjermund, Grøtting Arnstein, Dunker Øystein, Sandvik Jorunn, Nilsen Kristian B
Department of Neurology and Clinical Neurophysiology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Department of Neuromedicine and Movement Science, Faculty of Medicine and Health, Norwegian University of Science and Technology, Trondheim, Norway.
Muscle Nerve. 2025 Jun;71(6):1052-1062. doi: 10.1002/mus.28403. Epub 2025 Mar 27.
INTRODUCTION/AIMS: The association between body mass index (BMI) and nerve conduction study (NCS) amplitudes has not been adequately studied in overweight and obese subjects. Our aim was to estimate the impact of high BMI on NCS amplitudes and NCS summary measures.
One hundred and seventy-five patients with previous gastric bypass surgery and 86 subjects from the general population had clinical evaluations and NCS of upper and lower limbs. Subjects with diabetes, mononeuropathy, or polyneuropathy (PNP) were excluded. Eighty-three former patients with a mean age of 48 years (SD 8), BMI mean = 34.3 kg/m (range 22-60) and 62 control subjects from the general population with a mean age of 55 years (SD 11), BMI mean = 26.6 kg/m (range 19-40), were analyzed. Several Z-compounds were calculated from NCS parameters. Multiple linear regression models compared the impact of BMI on NCS amplitude measurements, corrected for height and age, and NCS-based Z-compounds.
Most sensory amplitudes and tibial nerve motor amplitude decreased significantly with increasing BMI. The magnitudes of association were comparable for BMI and age. A new Z-compound for sensory amplitudes correlated moderately strongly with BMI for subjects with BMI < 30 kg/m and BMI ≥ 30 kg/m (standardized beta 0.55 and 0.47 respectively, p < 0.0005).
Sensory NCS amplitudes depend on BMI in obese and non-obese subjects. Lower reference limits for several sensory amplitudes should probably be adjusted for BMI. Reference limits for amplitude-dependent Z-compounds should be corrected for BMI. The findings have relevance for all patients investigated with nerve conduction studies, in particular, patients with suspected axonal polyneuropathies.
引言/目的：体重指数（BMI）与神经传导研究（NCS）波幅之间的关联在超重和肥胖受试者中尚未得到充分研究。我们的目的是评估高BMI对NCS波幅和NCS汇总指标的影响。
175例曾接受胃旁路手术的患者和86名普通人群受试者接受了临床评估以及上下肢的NCS检查。排除患有糖尿病、单神经病或多发性神经病（PNP）的受试者。分析了83例平均年龄为48岁（标准差8）、BMI平均为34.3kg/m²（范围22 - 60）的既往患者以及62名平均年龄为55岁（标准差11）、BMI平均为26.6kg/m²（范围19 - 40）的普通人群对照受试者。从NCS参数计算了几种Z化合物。多元线性回归模型比较了BMI对NCS波幅测量值的影响，并对身高和年龄进行了校正，以及基于NCS的Z化合物。
随着BMI的增加，大多数感觉波幅和胫神经运动波幅显著降低。BMI和年龄的关联程度相当。一种新的感觉波幅Z化合物与BMI < 30kg/m²和BMI≥30kg/m²的受试者的BMI中度强烈相关（标准化β分别为0.55和0.47，p < 0.0005）。
肥胖和非肥胖受试者的感觉NCS波幅取决于BMI。几种感觉波幅的较低参考限值可能应根据BMI进行调整。与波幅相关的Z化合物的参考限值应根据BMI进行校正。这些发现与所有接受神经传导研究的患者相关，尤其是疑似轴索性多发性神经病的患者。
