Division of Thyroid Surgery, Department of General Surgery and Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Division of Thyroid Surgery, Department of General Surgery and Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Pharmacol Res. 2024 Nov;209:107449. doi: 10.1016/j.phrs.2024.107449. Epub 2024 Oct 4.
Cancer treatment remains a formidable challenge in modern medicine, necessitating a nuanced understanding of its molecular underpinnings and the identification of novel therapeutic modalities. Among the intricate web of cellular pathways implicated in oncogenesis, protein synthesis has emerged as a fundamental process warranting meticulous investigation. This review elucidates the multifaceted role of protein synthesis pathways in tumor initiation and progression, highlighting the potential of targeting key nodes within these pathways as viable therapeutic strategies. Natural products have long served as a source of bioactive compounds with therapeutic potential owing to their structural diversity and evolutionary honing. Within this framework, we provide a thorough examination of natural inhibitors of protein synthesis as promising candidates for cancer therapy, drawing upon recent advancements and mechanistic insights. By synthesizing current evidence and elucidating key challenges and opportunities, this review aims to galvanize further research into the development of natural product-based anticancer therapeutics, thereby advancing the clinical armamentarium against malignancies.
癌症治疗仍然是现代医学的一个巨大挑战，需要对其分子基础有细致的理解，并确定新的治疗方式。在涉及肿瘤发生的复杂细胞途径网络中，蛋白质合成已成为一个需要仔细研究的基本过程。本综述阐明了蛋白质合成途径在肿瘤起始和进展中的多方面作用，强调了靶向这些途径中的关键节点作为可行治疗策略的潜力。天然产物由于其结构多样性和进化优化，一直是具有治疗潜力的生物活性化合物的来源。在这个框架内，我们对蛋白质合成的天然抑制剂进行了全面的研究，这些抑制剂是癌症治疗的有前途的候选药物，借鉴了最近的进展和机制见解。通过综合当前的证据并阐明关键的挑战和机遇，本综述旨在激发更多针对天然产物为基础的抗癌治疗药物的研究，从而为对抗恶性肿瘤提供更多的临床武器。
